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Cpg-oligodeoxynucleotide, immunogenic composition comprising the same, and methods for preparing the composition and stimulating immune response thereby

An immune composition and immune response technology, applied in biochemical equipment and methods, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as low activity and achieve the effect of fewer side effects

Pending Publication Date: 2021-01-26
NAT INST OF HEALTH REPRESENTED BY THE SEC OF THE DEPT OF HEALTH & HUMAN SERVICES NAT INST OF HEALTH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Existing studies have shown that compared with human (h)TLR9 and mouse (m)TLR9, rabbit (rab) TLR9 has a wider ligand recognition profile (ligand recognition profile) for CpG-ODN with GTCGTT motif or GACGTT motif ; however, CpG-ODNs currently developed to activate human or mouse cells have low activity against rabTLR9 (14)

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  • Cpg-oligodeoxynucleotide, immunogenic composition comprising the same, and methods for preparing the composition and stimulating immune response thereby
  • Cpg-oligodeoxynucleotide, immunogenic composition comprising the same, and methods for preparing the composition and stimulating immune response thereby
  • Cpg-oligodeoxynucleotide, immunogenic composition comprising the same, and methods for preparing the composition and stimulating immune response thereby

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Embodiment Construction

[0060] The technical content of the present invention will become apparent through the detailed description of the following embodiments and the illustrations of the related drawings.

[0061] definition

[0062] "About" or "approximately," when used in connection with a measurable numerical variable, refers to the indicated value of the variable and within experimental error of the indicated value (e.g., a 95% confidence interval for the mean) or within the indicated value. All values ​​of the variable within 10% of the value, from which the maximum is taken.

[0063] "Adjuvant" refers to any substance that enhances the humoral or cellular immune response to an antigen. Adjuvants are generally used for two purposes: to delay the release of antigens from the injection site, and to stimulate the immune system.

[0064] "Antibody" refers to an immunoglobulin molecule capable of binding a specific antigen as a result of an immune response to that antigen. Immunoglobulins are s...

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Abstract

CpG-oligodeoxynucleotides (CpG-ODN), as potent immune stimuli developed for using as adjuvant in different species, are disclosed herein. TLR9 is the cellular receptor for CpG-ODN, and current developed CpG-ODN has low activity to rabbit TLR9. Here, a type of CpG-ODN containing a GACGTT or AACGTT motif in about 11-14 deoxynucleotides was demonstrated to have potent immunostimulatory activity to rabbit TLR9, and capable of boosting a less toxic and potent antibody response in rabbits.

Description

[0001] The application number is 201480041044.7 (PCT application number is PCT / US2014 / 047271), the application date is July 18, 2014, and the invention name is "CpG oligodeoxynucleotide, immune composition containing it and composition for use" A divisional application of the invention patent application for the preparation of drugs for treatment to stimulate immune response". technical field [0002] Cross-references to related applications [0003] This application claims the benefit of US Provisional Application No. 61 / 856,268, filed July 19, 2013, the disclosure of which is hereby incorporated by reference in its entirety. [0004] The present invention relates generally to CpG oligodeoxynucleotides, immune compositions comprising CpG oligodeoxynucleotides, methods for preparing immune compositions and methods for stimulating immune responses, in particular CpG comprising a GACGTT or AACGTT motif Oligodeoxynucleotides, immune compositions comprising CpG oligodeoxynucleoti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61P37/04
CPCA61K39/39A61K2039/55561A61P37/04A61K2039/55505C12N15/117C12N2310/17
Inventor 庄宗显赖朝阳
Owner NAT INST OF HEALTH REPRESENTED BY THE SEC OF THE DEPT OF HEALTH & HUMAN SERVICES NAT INST OF HEALTH
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