Microfluidic ultrasonic electrochemical on-chip laboratory analysis platform

A sonoelectrochemical and laboratory technology, which is applied in the direction of laboratory appliances, laboratory containers, and electrochemical variables of materials, to achieve the effects of improved sensitivity, good fastness, and precise thickness control

Pending Publication Date: 2021-01-08
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] To sum up, there is currently no microfluidic electrochemical laboratory-on-chip analysis platform integrated with ultrasonic emitting devices, and related solutions are needed

Method used

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  • Microfluidic ultrasonic electrochemical on-chip laboratory analysis platform
  • Microfluidic ultrasonic electrochemical on-chip laboratory analysis platform
  • Microfluidic ultrasonic electrochemical on-chip laboratory analysis platform

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Such as Figure 4 with 14As shown, a microfluidic sonoelectrochemical laboratory-on-chip analysis platform includes: an electrochemical sensor chip 6 and a microfluidic assembly 4 and a supporting substrate 2 arranged in parallel, an electrochemical sensor chip 6, a microfluidic assembly 4 and the support substrate 2 are arranged in sequence from top to bottom, wherein a micro-ultrasonic device 2-1 is arranged on the top surface of the support substrate 2, and a through hole is formed on the micro flow channel assembly 4, and the height of the through hole is 10 μm to 10 mm. The width of the through hole is 1mm˜10mm. The hole wall of the through hole forms a cavity 4-3 (that is, up and down) that is open at the top and bottom. The cavity 4-3 is used for ultrasonic electrochemical detection, and the cavity 4-3 is connected with microfluidic ultrasonic testing. The electrochemical on-chip laboratory analysis platform communicates with the outside, so that the liquid to ...

Embodiment 2

[0071] On the basis of Example 1, such as Figure 5 As shown, a liquid inlet chamber 4-1 and a liquid outlet chamber 4-2 are formed in the microchannel assembly 4, the liquid inlet chamber 4-1 communicates with the chamber body 4-3 through a first channel 4-4, and the liquid outlet chamber 4-2 communicates with the chamber 4-3 through a second channel 4-5, and the chamber 4-3 communicates with the microfluidic sonoelectrochemical laboratory-on-chip analysis platform through the liquid inlet chamber 4-1 and the liquid outlet chamber 4-2 The outside is connected.

[0072] The liquid inlet chamber 4-1, the liquid outlet chamber 4-2, the chamber body 4-3, the first channel 4-4 and the second channel 4-5 jointly form a micro flow channel, and the first channel 4-4 and the second channel 4 -5 have a width of 10 μm to 1 mm, the lengths of the first channel 4-4 and the second channel 4-5 are respectively 2 mm to 2 cm, and the liquid inlet chamber 4-1 and the liquid outlet chamber 4-2...

Embodiment 3

[0075] On the basis of embodiment 2, it also includes: an electrochemical sensor area limiting assembly 5 parallel to the micro flow channel assembly 4, a first opening 5-1 is formed on the electrochemical sensor area limiting assembly 5, the first opening 5-1 Set opposite to the sensing area of ​​the three electrodes, the electrochemical sensor chip 6 and the micro-ultrasonic device 2-1 are set in parallel or non-parallel, wherein:

[0076] When arranged in parallel, the electrochemical sensor area limiting component 5 can determine the area of ​​the sensing area of ​​the three electrodes exposed in the cavity 4-3, and the liquid to be measured can pass through the first opening 5-1 and the sensing area of ​​the three electrodes. Sensing area contact, the size of the first opening 5-1 is greater than or equal to the size of the sensing area of ​​the three electrodes and less than or equal to the size of the cross-section of the through hole, such as Figure 8 As shown, the sh...

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Abstract

The invention discloses a microfluidic ultrasonic electrochemical on-chip laboratory analysis platform, which comprises an electrochemical sensor chip, a micro-channel assembly and a supporting substrate, wherein the micro-channel assembly and the supporting substrate are arranged in parallel, the electrochemical sensor chip, the micro-channel assembly and the supporting substrate are sequentiallyarranged from top to bottom, a miniature ultrasonic device is arranged on the top surface of the supporting substrate, a through hole is formed in the micro-channel assembly, a cavity with an open top end and an open bottom end is defined by the hole wall of the through hole, the cavity is communicated with the outside of the microfluidic ultrasonic electrochemical on-chip laboratory analysis platform so as to discharge a to-be-detected liquid into and out of the cavity, and the to-be-detected liquid in the cavity can be in contact with the three electrodes of an electrochemical sensor chip and the vibration area of a micro ultrasonic device. According to the invention, the combined use of the micro ultrasonic device and the electrochemical sensor chip is realized, the electrochemical sensing sensitivity is effectively improved, and the liquid inlet and outlet is opened in the vertical direction of the micro-channel assembly, so that the micro-channel assembly can be applied to the design of a small-thickness micro-fluidic on-chip laboratory.

Description

technical field [0001] The invention belongs to the technical field of microfluidic electrochemical analysis, and in particular relates to a microfluidic sonoelectrochemical on-chip laboratory analysis platform. Background technique [0002] Microfluidic lab on a chip (microfluidic lab on a chip) integrates basic operation units such as micro sample preparation, reaction, separation, detection, and waste liquid recovery into one chip to realize automatic analysis and avoid potential cross-contamination and artificial The impact of operating errors is widely used in the fields of chemical, biological, and medical analysis. In the microfluidic laboratory on a chip, the liquid flows in the microchannel, and the size of the microchannel perpendicular to the flow direction of the liquid usually needs to be less than 1mm. [0003] The electrochemical sensor chip (working, comparison, and reference electrodes on the same substrate) has the advantages of small size, low energy cons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N27/48
CPCB01L3/5027G01N27/48
Inventor 牛鹏飞佘祥庞慰王小荷郑宗威
Owner TIANJIN UNIV
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