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Traditional Chinese medicine composition for improving vaginal microecology, preparation and application thereof

A composition and microecological technology, applied in the directions of drug combination, drug delivery, medical preparations containing active ingredients, etc., can solve problems such as drug resistance and increased recurrence rate, and achieve improved immunity, strong inhibitory effect, and promotion of The effect of microbial ecological balance

Active Publication Date: 2021-01-08
上海松皓生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine treats these inflammations mainly with azole antifungal drugs orally or locally, with quick onset and definite curative effect, but there are limitations such as gastrointestinal reactions, liver and kidney toxicity, drug resistance and increased recurrence rate

Method used

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  • Traditional Chinese medicine composition for improving vaginal microecology, preparation and application thereof
  • Traditional Chinese medicine composition for improving vaginal microecology, preparation and application thereof
  • Traditional Chinese medicine composition for improving vaginal microecology, preparation and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0037] The preparation process of recombinant hirudin is carried out in a shaker flask, and the rotating speed is 650r / min;

[0038] The inoculum amount of seed liquid is 11%;

[0039] The preparation method of seed liquid is: the preparation method of seed liquid is: (1) inoculate engineered bacterium glycerol preservation bacterium to the 100mL Erlenmeyer flask that 5mL seed medium is housed, at 30 ℃, 220rpm shaker culture 24 hours; (2) Transfer to a 250mL Erlenmeyer flask containing 50mL of seed medium, and cultivate at 30°C for 24 hours on a shaker at 220rpm; (3) transfer to a 1000mL Erlenmeyer flask containing 250mL of seed medium (two bottles in total), Cultivate on a shaker at 30°C and 220rpm for 12 hours to obtain the seed solution to be inoculated;

[0040] Seed medium comprises glucose, YNB, amino acid and water, and the sucrose content in the seed medium is 20g / L of the total volume of the solution of initial medium; The weight ratio of glucose, YNB, amino acid is ...

Embodiment 1

[0075] Embodiment 1 provides a kind of lotion that improves vaginal microecology, and comprises the following components by weight percentage: decyl glucoside 0.06%, sodium cocoamphoacetate 2%, sodium myristeth sulfate 2%, panthenol 0.2%, PEG-200 hydrogenated glyceryl palmitoleate 2%, PEG-40 hydrogenated castor oil 1%, polyquaternium-10 0.5%, sodium benzoate 0.5%, recombinant hirudin fermentation broth 5% , Lactobacillus fermentation broth 5%, traditional Chinese medicine extract 0.33%, water supplement 100%.

[0076] The preparation method of the recombinant hirudin fermentation liquid is as follows: the seed liquid is placed in the initial culture medium, passed through sterile air, and the DO value is kept greater than 40%; when the DO value is greater than 55%, the initial culture medium is passed through flow The feeding medium was added dropwise; wherein, the ventilation rate of sterile air was 5L / min, the temperature of the initial medium was 30°C, and the pH of the ini...

Embodiment 2

[0106]The difference between Example 2 and Example 1 is that the content of the Chinese medicine composition in the lotion is 8wt%; the Chinese medicine composition is a mixture of recombinant hirudin fermented liquid, lactobacillus fermented liquid and Chinese medicine extract, and the weight ratio 1:0.5:0.01; the Chinese medicine extract is a mixture of Sophora flavescens extract, Cortex Phellodendri extract, Fructus Cnidii extract, Zanthoxylum bungeanum extract, Peppermint extract, Angelica sinensis extract, Comfrey extract, and the weight ratio is 1 :0.5:0.5:0.1:0.5:0.5:0.5.

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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving vaginal microecology, a preparation and application thereof. The traditional Chinese medicine composition for improving vaginal microecology at least comprises the following components of recombinant hirudin fermentation liquor, lactobacillus fermentation liquor and a traditional Chinese medicine extract. The traditional Chinese medicine composition for improving vaginal microecology has the effects of resisting bacteria, diminishing inflammation, improving immunity and promoting microbial ecological balance, and clinical tests show that the traditional Chinese medicine composition has good effects on pruritus vulvae, abnormal leucorrhea and trichomonas vaginitis of women; and microbial tests find that the traditional Chinese medicine composition has a very strong inhibition effect on pathogenic bacteria candida albicans of vaginitis and has no inhibition on lactic acid property of probiotics of vagina.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, preparation and application for improving vaginal microecology. Background technique [0002] Female vulvovaginal inflammation is a common gynecological disease, which has the characteristics of multiple recurrences, difficult to cure, and prone to antifungal drug resistance. Western medicine treats these inflammations mainly with azole antifungal drugs taken orally or locally, with quick onset and definite curative effect, but there are limitations such as gastrointestinal reactions, liver and kidney toxicity, drug resistance and increased recurrence rate. What's more serious is that these antibiotic ingredients can destroy the vaginal microbial bacterial system. The vaginal micro-ecological system is a unique, dynamic micro-ecological system with a pH value between 3.8 and 4.4. This weakly acidic environment can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/58A61P15/02A61P17/04A61P33/02A61P31/10A61P31/02A61P15/00A61K35/747A61K36/758A61K36/9066
CPCA61K38/58A61K35/747A61K36/78A61K36/28A61K36/73A61K36/756A61K36/489A61K36/234A61K36/758A61K36/86A61K36/534A61K36/30A61K36/75A61K36/185A61K36/15A61K36/902A61K36/9066A61K36/232A61K36/515A61K9/0034A61P15/02A61P17/04A61P33/02A61P31/10A61P31/02A61P15/00A61K2300/00Y02A50/30
Inventor 杨爱岗刘茜
Owner 上海松皓生物科技有限公司
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