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Extract containing liquiritin and preparation method of extract

A technology of extract and liquiritin, which is applied in the field of extraction and separation of traditional Chinese medicine, can solve the problems of difficulty in realizing the utilization rate of licorice and low content of liquiritin, and achieve good extraction effect and high extraction rate

Active Publication Date: 2020-12-18
大湾汉唯(广州)医药科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above documents, it can be seen that the extraction method using butanediol as an ultrasonic extraction solvent is disclosed. Of course, in addition to butanediol, in the prior art, the frequently used extraction solvent is methanol or ethanol. The applicant found that after The content of liquiritin in the extract containing liquiritin extracted by the extraction method in the existing literature is low, and it is difficult to realize the utilization rate of licorice medicine, so how to increase the content of liquiritin in the extract containing liquiritin is of great value and meaning

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Put 1Kg of licorice in a container, add 5L of deionized water, stir well, then add 5L of extraction solvent and stir well to make a mixed solution, wherein the extraction solvent is a mixed solution of ethanol, isopropanol and acetone , wherein the volume ratio of ethanol, isopropanol and acetone is 90:7:3;

[0026] (2) Pour the above mixed solution into the ultrasonic reaction kettle, control the temperature in the kettle at 65°C, adjust the power of the ultrasonic transmitter to 600W, set the ultrasonic emission frequency to 25KHz, start the ultrasonic program, and make the mixed solution generate vortex under the condition of Ultrasonic treatment for 90 min to obtain treatment solution Ⅰ;

[0027] (3) Cool the above-mentioned treatment solution I to 20°C, add an extraction solvent with the same volume as the above-mentioned treatment solution I again, continue stirring for 90 minutes, and keep the temperature at 20°C to obtain the treatment solution II; wherein, ...

Embodiment 2

[0031] (1) Put 1Kg of licorice in a container, add 2L of deionized water, stir well, then add 3L of extraction solvent and stir well to make a mixed solution, wherein the extraction solvent is a mixed solution of ethanol, isopropanol and acetone , wherein the volume ratio of ethanol, isopropanol and acetone is 85:10:5;

[0032] (2) Pour the above mixed solution into the ultrasonic reaction kettle, control the temperature in the kettle at 60°C, adjust the power of the ultrasonic transmitter to 800W, set the ultrasonic transmission frequency to 20KHz, start the ultrasonic program, and make the mixed solution generate vortex under the condition of Ultrasonic treatment for 60 min to obtain treatment solution Ⅰ;

[0033](3) Cool the above treatment solution I to 16°C, add 1.2 times the volume of the extraction solvent of the above treatment solution I again, continue stirring for 120 min, and keep the temperature at 16°C to obtain the treatment solution II; wherein, the extraction ...

Embodiment 3

[0037] (1) Put 1Kg of licorice in a container, add 9L of distilled water, stir well, then add 6L of extraction solvent and stir well to make a mixed solution, wherein the extraction solvent is a mixed solution of ethanol, isopropanol and acetone, wherein , the volume ratio of ethanol, isopropanol and acetone is 95:4:1;

[0038] (2) Pour the above mixed solution into the ultrasonic reaction kettle, control the temperature in the kettle at 70°C, adjust the power of the ultrasonic transmitter to 400W, set the ultrasonic emission frequency to 30KHz, start the ultrasonic program, and make the mixed solution generate vortex under the condition of Ultrasonic treatment for 120 min to obtain treatment solution Ⅰ;

[0039] (3) Cool the above-mentioned treatment solution I to 26°C, add 0.8 times the volume of the extraction solvent of the above-mentioned treatment solution I again, continue stirring for 60 minutes, and keep the temperature at 26°C to obtain the treatment solution II; whe...

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PUM

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Abstract

The invention discloses a preparation method of an extract containing liquiritin. The preparation method comprises the following steps: taking a mixed solution of ethanol, isopropanol and acetone as an extraction solvent, controlling the volume ratio of ethanol to the isopropanol to the acetone to be (85-95): (4-10): (1-5), and further comprehensively extracting the extract containing liquiritin twice under different conditions, so as to obtain the extract containing liquiritin. The content rate of the liquiritin in the extract containing Liquiritin is 35.82% or above. Besides, a gradient heating mode is adopted in the first ultrasonic treatment process, so that the content of the liquiritin in the extract is further increased. Furthermore, the invention also discloses the extract containing the Liquiritin, obtained by the preparation method.

Description

technical field [0001] The invention relates to the technical field of extraction and separation of traditional Chinese medicines, in particular to a preparation method for extracting a liquiritin-containing extract from licorice and the liquiritin-containing extract extracted by the method. Background technique [0002] Liquiritin (Liquiritin, systematically named: 4',7-dihydroxyflavone-4'-O-β-D-glucopyranoside) is the most important flavonoid in licorice, belonging to dihydroflavonoids, Has strong pharmacological activity. Liquiritin has anti-oxidation, anti-arrhythmia, anti-ulcer, anti-virus, neuroprotection, myocardial cell membrane protection and other effects. Although liquiritin has a variety of pharmacological activities, many problems still need to be solved in order to develop it into a new drug, one of the main problems is the extraction process. For the extraction process, the types used in the prior art are various, as Chinese patent document CN101073595A disc...

Claims

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Application Information

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IPC IPC(8): C07H15/26C07H1/08A61K36/484
CPCA61K36/484A61K2236/333A61K2236/39A61K2236/51A61K2236/53C07H1/08C07H15/26
Inventor 刘昌孝董佳琪刘姝含徐明恺董汉玉
Owner 大湾汉唯(广州)医药科技集团有限公司
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