Compound extracted and separated from parthenocissus tricuspidata and application of compound in preparation of anti-diabetic drugs

Abstract

The invention relates to the technical field of medicinal compounds, and particularly discloses a new compound 3beta, 23-dihydroxy-28-norolean-12-ene-16-one extracted and separated from parthenocissustricuspidata, and an application of the new compound in preparation of an anti-diabetic drug. Modern spectrum technologies such as 1D-NMR, 2D-NMR, high-resolution mass spectrum and the like are adopted to carry out structure identification on the separated monomeric compound, and the molecular structure of the compound is derived. An enzyme activity experiment result shows that the new compound has better activity of inhibiting protein tyrosine phosphatase 1B (PTP1B) and alpha-glucosidase. Molecular docking results show that the new compound has good binding activity with a target protein, and the interaction force is mainly hydrogen bonds and hydrophobic forces. The new compound has a good hypoglycemic effect, and has a good application prospect in the aspect of treating diabetes mellitus.

Description

technical field [0001] The invention relates to the technical field of medicinal compounds, in particular to a new compound 3β,23-dihydroxy-28-norolean-12-ene-16-one (3β,23-dihydroxy-28-one (3β,23-dihydroxy-28- Norcarb-olean-12-en-16-one) and the application of the new compound in the preparation of antidiabetic drugs. Background technique [0002] Caulophyllum robustum Maxim. is the root and rhizome of Berberidaceae plant Caulophyllum robustum Maxim. It is also known as Caulophyllum robustum Maxim. Hongmaoqi is mainly produced in Heilongjiang, Shaanxi, Liaoning, Gansu, Hubei and other places. It grows in the shade and damp places of ravines at an altitude of about 950-3500 meters, under forests or under bamboo forests. It is used as a Tujia national medicine in Hubei Province. Its roots and rhizomes are used as medicines. It has the functions of expelling wind and dampness, clearing away heat and detoxification, promoting blood circulation and removing blood stasis, loweri...

AI Technical Summary

Problems solved by technology

[0004] At present, scholars at home and abroad are mainly studying the biological activity of the traditional Chinese medicine Hongmaoqi. There are few studies on the specific pharmacological activities of the chemical components contained in it. It is mostly used in combination with other medicinal materials. The components are complex and its mechanism of action is still unclear. There are no relevant literatures about the anti-diabetic effects of triterpenoid saponins, and the structure of the triterpenoids has strong specificity. Therefore, starting from the isolation and identification of the monomeric compounds, find the active ingredients that exert various medicinal effects , in order to conduct in-depth research, development and utilization, it is of great significance

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