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Eye care composition as well as preparation method and application thereof

An eye care and composition technology, applied in the field of eye care composition and preparation thereof, can solve the problems of corneal fungal infection, overgrowth of non-sensitive microorganisms, etc., and achieves repairing corneal damage, preventing wound infection, and inhibiting reactive inflammation. Effect

Active Publication Date: 2020-11-27
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also the possibility of fungal infection of the cornea, as with antibiotics, long-term use may lead to overgrowth of non-susceptible microorganisms

Method used

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  • Eye care composition as well as preparation method and application thereof
  • Eye care composition as well as preparation method and application thereof
  • Eye care composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Add 100ml of water for injection into the dissolving tank, add 0.01g of sodium hyaluronate (molecular weight: 1.8 million Da) into the water, stir until completely dissolved; mix 5g of ectoine, 0.05g of chondroitin sulfate, and 0.5g of sodium borate buffer solution , 0.05g of sodium chloride, 0.001g of benzalkonium chloride, 0.02g of taurine, 0.02g of vitamin B6 and 0.06g of vitamin B12 are slowly added to the dissolving tank, mixed evenly, stirred to make it all dissolve, and a mixed solution;

[0055] Hydrochloric acid was used to fine-tune the pH of the mixed solution to 6.5, and the ophthalmic care composition was obtained by filtration, and its osmotic pressure was 290 mOsm / L.

Embodiment 2-6

[0057] The difference between Examples 2-6 and Example 1 is that the amounts of sodium hyaluronate, ectoine and chondroitin sulfate added are different, as shown in Table 1 for details. The amount and preparation method of other components are the same as in Example 1.

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Abstract

The invention provides an eye care composition. The eye care composition is prepared from chondroitin sulfate, hyaluronic acid and ectoin or an ophthalmologically acceptable ectoin derivative. In theeye care composition, the chondroitin sulfate accounts for 0.05 to 2 percent by mass preferably 0.1%-1%; the mass percentage of the hyaluronic acid is 0.01%-2.5%, preferably 0.05%-1.5%; and the masspercentage of the ectoine or the ophthalmologically acceptable ectoine derivative is 0.5%-5%, preferably 0.5%-2%. Compared with the prior art, according to the eye care composition disclosed by the invention, hyaluronic acid, ectoin and chondroitin sulfate are combined according to a certain weight ratio, so that the repair of corneal injury can be accelerated; the anti-fatigue effect is remarkable, the recovery time of iris congestion and swelling is short, and the growth of escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and candida albicans is well inhibited. More importantly, the irritation of chondroitin sulfate can be obviously relieved.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to an eye care composition and its preparation method and application. Background technique [0002] Endophthalmitis is a common complication after ophthalmic surgery. For example, the probability of endophthalmitis after cataract surgery is 0.2% to 0.5%, and the severity of inflammatory reactions after inner eye surgery is inevitable. Intraocular surgery cuts ocular tissues such as conjunctiva, cornea, sclera, and inevitably damages or stimulates intraocular tissues such as iris during surgery, which will cause damage to ocular tissues, tissue hyperemia, edema, reactive exudation, etc. and cause eye irritation and discomfort. After ophthalmic surgery, the wound should be kept clean, and the blood scab and secretions should be cleaned in time to prevent infection and promote wound recovery. Therefore, antibiotics or hormone eye drops and eye ointment are commonly used after ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K31/015A61K31/047A61K31/07A61K31/185A61K31/355A61K31/505A61K31/728A61K47/36A61K47/22A61P27/02A61P31/04
CPCA61K31/737A61K31/728A61K31/505A61P27/02A61P31/04A61K31/07A61K31/355A61K31/185A61K31/047A61K31/015A61K47/36A61K47/22A61K2300/00Y02A50/30
Inventor 王静耿凤邵萌郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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