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High-flexibility stitch closure line and production technology thereof

A highly flexible, seam technology, applied in coating, medical science, surgery, etc., can solve the problems of increasing wound healing time, easy growth of bacteria in wounds, and secondary wounds.

Inactive Publication Date: 2020-11-17
安徽正美线业科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] After the existing sutures are sutured, some of the wounds are relatively deep, which makes the wound heal for a long time, which brings great inconvenience to the injured, and the wound is easy to breed bacteria, causing secondary damage to the wound, thereby increasing the wound healing time

Method used

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  • High-flexibility stitch closure line and production technology thereof
  • High-flexibility stitch closure line and production technology thereof
  • High-flexibility stitch closure line and production technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A highly flexible suture line is made by the following steps:

[0047] Step S1: Pulverize the fish skin, soak in sodium hydroxide solution for 20 hours, filter and remove the filtrate, stir the filter cake with hydrochloric acid solution for 20 hours, wash with deionized water until the pH value is 7, and wash with ether solution After soaking for 20 hours, remove the filtrate by filtration, soak the filter cake in acetic acid solution for 2 days, then centrifuge for 10 minutes at a speed of 5000r / min, take the supernatant, and freeze-dry it at minus 15°C Collagen peptides were prepared;

[0048] Step S2: Add montmorillonite and sodium chloride solution into the reaction kettle, stir for 2 hours under the condition of rotating speed of 300r / min and temperature of 35°C, filter and remove the filtrate, and wash the filter cake with deionized water After no chlorine ions remain on the surface, add the filter cake to the silver nitrate solution, stir for 5 hours at a speed...

Embodiment 2

[0060] A highly flexible suture line is made by the following steps:

[0061] Step S1: crush the fish skin, add it to sodium hydroxide solution for soaking for 23 hours, filter and remove the filtrate, stir the filter cake with hydrochloric acid solution for 23 hours, wash it with deionized water until the pH value is 7, and wash it with ether solution After soaking for 23 hours, remove the filtrate by filtration, soak the filter cake in acetic acid solution for 2 days, then centrifuge for 13 minutes at a speed of 6000r / min, take the supernatant, and freeze-dry it at minus 18°C Collagen peptides were prepared;

[0062] Step S2: Add montmorillonite and sodium chloride solution into the reaction kettle, and stir for 2.5 hours under the conditions of rotation speed of 400r / min and temperature of 38°C, then filter to remove the filtrate, and deionize the filter cake with deionized water After washing until no chlorine ions remain on the surface, add the filter cake to the silver ...

Embodiment 3

[0067] A highly flexible suture line is made by the following steps:

[0068]Step S1: Pulverize the fish skin, add it to sodium hydroxide solution for soaking for 25 hours, filter and remove the filtrate, stir the filter cake with hydrochloric acid solution for 25 hours, wash it with deionized water until the pH value is 7, and wash it with ether solution After soaking for 25 hours, remove the filtrate by filtration, soak the filter cake in acetic acid solution for 3 days, then centrifuge for 15 minutes at a speed of 6000r / min, take the supernatant, and freeze-dry it at minus 20°C Collagen peptides were prepared;

[0069] Step S2: Add montmorillonite and sodium chloride solution into the reaction kettle, stir for 3 hours under the conditions of rotation speed of 500r / min and temperature of 40°C, filter and remove the filtrate, and wash the filter cake with deionized water After no chlorine ions remain on the surface, add the filter cake to the silver nitrate solution, stir fo...

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Abstract

The invention discloses a high-flexibility stitch closure line and a production technology thereof. In a stitch closure line production process, an antibacterial agent is prepared and is prepared in away that chitosan is taken as a carrier to carry an intermediate 5; when the stitch closure line is used for suturing a wound, cells on the wound can absorb carboxymethyl cellulose on a micro-capsule, and the micro-capsule disintegrates to release collagen and the antibacterial agent; the antibacterial agent is of a gel form and can be attached to the surface of the wound, so that the intermediate 5 can be released and acts on bacteria DNA gyrase, and DNA duplication is disturbed to cause bacteria to die; and meanwhile, the intermediate 5 can break a cell serous membrane, bacteria content runs off to cause the bacteria to die, so that a wound suturing part is free from bacteria infection, wound healing speed is improved, in addition, the stitch closure line has good flexibility, and the wound can be easily recovered.

Description

technical field [0001] The invention belongs to the technical field of seam preparation, and in particular relates to a highly flexible seam and a production process thereof. Background technique [0002] Suture thread refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] After the existing sutures are sutured, some of the wounds are relatively deep, which makes the wound heal for a long time, which brings great inconvenience to the injured, and the wound is easy to breed bacteria, causing secondary damage to the wound, thereby increasing the time for the wound to heal. Contents of the invention [0004] The object of the present invention is to provide a highly flexible seam line and its production process. [000...

Claims

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Application Information

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IPC IPC(8): A61L17/04A61L17/00A61L17/08A61L17/10A61L17/14
CPCA61L17/005A61L17/04A61L17/08A61L17/10A61L17/145A61L2300/204A61L2300/404A61L2420/02A61L2420/04C08L5/08
Inventor 崔四明魏彩英
Owner 安徽正美线业科技股份有限公司
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