Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chinese herbal medicine extract, extraction method and application

A technology for extracting and extracting Chinese herbal medicines, which can be applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as neurodegenerative disease hazards, and achieve the effects of large social and economic benefits and simple operation.

Active Publication Date: 2020-11-17
SOUTHWEST MEDICAL UNIVERISTY
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of Chinese herbal medicine extract and its extraction method, as well as the method of extracting the natural Chinese herbal medicine extract in view of the severe neurodegenerative diseases in the prior art and the urgent need to develop neuroprotective medicines from Chinese herbal medicines. Separation and purification methods and uses

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chinese herbal medicine extract, extraction method and application
  • Chinese herbal medicine extract, extraction method and application
  • Chinese herbal medicine extract, extraction method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Pulverize 2.5kg of air-dried Hydrangea, use 10 times the volume of 75% ethanol to reflux extract for 1.5 hours, repeat 3 times. After the extraction, all the extraction solutions were combined, filtered, and concentrated to dryness by a rotary evaporator under vacuum at 60°C to obtain a crude extract of Hydrangea japonica.

[0098] The crude extract of lion grass was dissolved in water, extracted three times with petroleum ether (1:1vol / vol), and the petroleum ether layer was collected. The remaining water part was extracted three times with ethyl acetate (1:1 vol / vol) to obtain an ethyl acetate layer. Finally, the residual water part was extracted again with n-butanol (1:1 vol / vol) in 3 times to obtain the n-butanol layer and finally the remaining water layer. The resulting petroleum ether layer, ethyl acetate layer, n-butanol layer, and finally the remaining water layer were all desolventized and dried in vacuo. Petroleum ether fraction (PF, 136g), ethyl acetate fra...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a Chinese herbal medicine extract, an extraction method and application. The Chinese herbal medicine extract is separated and extracted from Japanese peristrophe herb, and ismainly a mixture of three lignan compounds, namely justicidin A, justicidin B and justicidin C. The extraction method comprises the following steps: performing reflux extraction on the Japanese peristrophe herb by using ethanol, extracting by using petroleum ether and ethyl acetate in sequence, performing silica gel column chromatography separation on the ethyl acetate layer obtained by extractionto obtain 34 fractions, and finally performing liquid chromatography purification on the eleventh fraction to obtain the Chinese herbal medicine extract. The Chinese herbal medicine extract providedby the invention can achieve a neuroprotective effect in a cell autophagy inducing mode. The extraction method is easy to operate.

Description

technical field [0001] The invention relates to the field of extraction and separation of natural medicinal compounds, in particular to a Chinese herbal medicine extract, extraction method and application. Background technique [0002] Nine Lion Grass (PJ) is a traditional folk Chinese herbal medicine, which contains flavonoids, alkaloids, organic acids, trace elements and other plant natural active ingredients. Modern pharmacological studies have shown that PJ has anti-inflammatory, antibacterial, enzyme-lowering, liver-protecting, and blood-pressure-lowering effects. [0003] Neurodegenerative diseases are a heterogeneous group of diseases characterized by the progressive loss of neurons. Such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Damaged nerve cells are often accompanied by serious diseases, such as cerebral infarction, cerebral hemorrhage, and brain atrophy. Seriously endanger human he...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61P25/28
CPCA61K36/19A61P25/28A61K2236/333A61K2236/55
Inventor 吴安国潘蓉秦大莲周晓钢唐勇吴建明何长龙邱文乔
Owner SOUTHWEST MEDICAL UNIVERISTY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com