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Medicine for treating tropical theileriosis and application

The invention relates to a sheep coccidiosis and drug technology, which is applied to the drug and application field for the treatment of sheep coccidiosis, and achieves the effects of improving economic benefits, reducing losses and improving the therapeutic effect.

Active Publication Date: 2020-11-06
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a risk in the immunization of the Theileria annulus vaccine in cattle. In a region or country, the introduction of an immune species that does not exist locally can make cattle become carriers of the parasite (or a certain parasite) , and spread by ticks

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation method of the medicine for the treatment of sheep pyrosomiasis of the present invention is:

[0016] Add appropriate amount of starch and other auxiliary materials to 4-methylumbelliferone to make tablets, each tablet contains 0.2g of 4-methylumbelliferone.

Embodiment 2

[0018] Toxicological test of the medicine for treating sheep pyrosomiasis of the present invention

[0019] 1. Test animals

[0020] 60 Kunming mice (common grade), half male and half male, weighing 18-22g. The experimental animals were adapted to feeding for 10 days before administration, and were fed quantitatively every day in a clean and quiet environment, and had free access to drinking water.

[0021] 2. Test method and test result

[0022] Acute toxicity test: In accordance with the UP-DOWN drug acute toxicity test rules, relevant experiments were carried out using Kunming mice to determine the LD 50 It is 3910mg / kg, with low toxicity.

[0023] Subacute Toxicity Test

[0024] The mice were fed with 4 times the clinical dosage (80 mg / kg) for a total of 30 days without any toxic or side effects. The mice had normal diet, behavior and feces, and developed well. It shows that the clinical dosage of the medicine of the present invention is safe.

Embodiment 3

[0026] An application test was carried out on 26 goats in Xincheng Town, Lintan County, Gansu Province. The results showed that the effect of applying 4-methylumbelliferone on sheep pyrosomiasis was better than that of applying triazamidine.

[0027] The clinical trial of the medicine that the present invention is used for the treatment of sheep pyrosomiasis:

[0028] 1. Materials and methods:

[0029] 1.1 Preparation of test drugs:

[0030] Medicine: 4-methylumbelliferone tablet prepared in Example 1 of the present invention.

[0031] 1.2 Experimental animals and groups:

[0032] Sheep pyrosomiasis is a highly seasonal endemic disease, and it is a tick-borne blood protozoan disease. Every spring, April is the season for sheep pyrosomiasis. The sick sheep are depressed, with loss of appetite or exhaustion. Most of the disease course is acute, and the body temperature rises to about 41°C, which is a persistent fever type. Sick sheep have shortness of breath, shallow and fas...

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PUM

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Abstract

The invention provides a medicine for treating tropical theileriosis. The effective component of the medicine is 4-methyl umbelliferone. The medicine disclosed by the invention has a good treatment effect on the tropical theileriosis, the recovery rate reaches 92.3% and is superior to that of the existing medicine triazamidine, the loss of farmers is reduced, and the economic benefits of the sheepfarmers are improved.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a medicine for treating sheep pyrosomiasis and its application. Background technique [0002] Pyrosomiasis, also known as Tropical theilerio-sis, is a tick-borne blood protozoan disease caused by Theileria annulate, which is endemic in North America and most of Central Asia and North Africa In my country, it is mainly distributed in the desert grasslands of 14 provinces (districts) north of the Yangtze River. The incidence rate in the epidemic area is 34.07% (17.8%-50%), generally more than 10%, and the mortality rate is 43.64% (16.6%). ~60%), generally above 30%. Sheep pyrosomiasis is a highly seasonal endemic disease, and the disease is mostly acute, characterized by persistent high fever, anemia and enlarged lymph nodes on the body surface. In Gannan, Gansu and Qinghai Tibetan pastoral areas, the incidence of the disease begins in early May every year, ...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61P33/02
CPCA61K31/37A61P33/02
Inventor 苗小楼尚小飞李芸王瑜汪晓斌潘虎李冰张继瑜宋德成
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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