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Application of glucose transporter 1 inhibitor WZB117 to preparation of cystic echinococcosis treating drug

A technology for glucose transport and cystic echinococcosis, applied in drug combinations, anti-infective drugs, pharmaceutical formulations, etc., can solve problems such as poor absorption, unsatisfactory treatment effect, and long-term use

Pending Publication Date: 2020-11-06
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides an application of glucose transporter 1 inhibitor WZB117 as a drug for treating cystic echinococcosis, which can effectively solve the problem that there is no relevant report on glucose transporter 1 inhibitor WZB117 as a drug for treating cystic echinococcosis At the same time, benzimidazoles have poor intestinal absorption, need to be taken for a long time, and are prone to drug resistance, which leads to unsatisfactory treatment effects

Method used

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  • Application of glucose transporter 1 inhibitor WZB117 to preparation of cystic echinococcosis treating drug
  • Application of glucose transporter 1 inhibitor WZB117 to preparation of cystic echinococcosis treating drug
  • Application of glucose transporter 1 inhibitor WZB117 to preparation of cystic echinococcosis treating drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1, the application of the glucose transporter 1 inhibitor WZB117 as a drug for the treatment of cystic echinococcosis.

Embodiment 2

[0031] Example 2, as an optimization of the above example, also includes the combined use of albendazole, glucose transporter 1 inhibitor WZB117 and albendazole.

Embodiment 3

[0032] Example 3, as an optimization of the above example, the mass ratio of glucose transporter 1 inhibitor WZB117 and albendazole is 1:8 to 1:1.

[0033] The application of the glucose transporter 1 inhibitor WZB117 as a drug for the preparation of cystic echinococcosis is tested as follows:

[0034] 1. In vitro experiment of glucose transporter 1 inhibitor WZB117

[0035] 1.1 WZB117 in vitro experiment

[0036] 1.1.1 Purpose of the experiment: To explore the survival rate of Echinococcus granulosus protoscoleum and vesicles in vitro with WZB117 at various concentrations for a period of 4 days

[0037] 1.1.2 Experimental grouping (overview)

[0038] This experiment was divided into 9 groups, namely WZB117 intervention group 1, WZB117 intervention group 2, WZB117 intervention group 3, WZB117 intervention group 4, WZB117 intervention group 5, WZB117 intervention group 6, ABZSO group, negative group and DMSO group; Three replicate wells were done in each group; the experimen...

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Abstract

The invention relates to the technical field of echinococcosis drugs, in particular to an application of a glucose transporter 1 inhibitor WZB117 to preparation of a cystic echinococcosis treating drug. The invention discloses the application of the WZB117 to preparation of the cystic echinococcosis treating drug for the first time. Pharmacodynamic experiment data in vivo and in vitro show that the WZB117 is an efficient echinococcosis-resistant drug molecule, and particularly has a remarkable treatment effect on cystic echinococcosis, and the effect is superior to that of albendazole sulfoxide which is an albendazole metabolite; the combined use of the WZB117 and the albendazole sulfoxide has a better synergistic treatment effect, and the effect is remarkably superior to that of independent administration of the WZB117 and independent administration of the albendazole sulfoxide; and meanwhile, the dosage of the combined use of the WZB117 and the albendazole sulfoxide is reduced by 1 / 3-1 / 2 compared with the dosage of the independent administration of the albendazole sulfoxide, so that the dosage and the drug resistance are greatly reduced, a good treatment effect is achieved, and the WZB117 can be used as an effective substitute for existing albendazole.

Description

technical field [0001] The invention relates to the technical field of echinococcosis drugs, and relates to the application of a glucose transporter 1 inhibitor WZB117 as a drug for treating cystic echinococcosis. Background technique [0002] Cystic echinococcosis (CE) is caused by Echinococcus granulosus ( Echinococcus granulosus ) larvae parasitic on livestock such as cattle and sheep or human body caused by zoonotic chronic parasitic diseases. The disease is distributed globally. It is mainly concentrated in the northwest agricultural and animal husbandry areas in China. The threatened population reaches 66 million, causing economic losses of more than 3 billion yuan each year. It is a serious public health problem that has attracted much attention. In 2006, the disease was included in the National Free Relief Program. [0003] The treatment methods for cystic echinococcosis mainly include surgical treatment and drug therapy, but surgical treatment has problems such ...

Claims

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Application Information

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IPC IPC(8): A61K31/235A61K31/4184A61P33/10
CPCA61K31/235A61K31/4184A61P33/10A61K2300/00
Inventor 吕国栋林仁勇王慧库尔班尼沙·阿马洪刘辉毕晓娟杨宁李亮
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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