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Arteriovenous fistula in-vitro hemodynamic physical simulation model device

An arteriovenous fistula and fluid dynamics technology, applied in the field of simulation, can solve problems such as long experimental period and inconsistent results

Active Publication Date: 2020-11-03
FUJIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] According to the literature at home and abroad, researchers at home and abroad are based on actual patients when conducting arteriovenous fistula research, but there is specificity among patients, and the data collected in the same period of internal fistula in different patients may cause inconsistent results; During the experiment, due to the periodicity of fistula establishment to maturity, the experiment period is long.

Method used

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  • Arteriovenous fistula in-vitro hemodynamic physical simulation model device
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  • Arteriovenous fistula in-vitro hemodynamic physical simulation model device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] In this example, the simulated blood is mixed glycerol water (38%-62% by volume) liquid. At 28°C, the viscosity is 3.2×10 -6 m 2 / s, and the density is 1090 kg / m 3 .

[0059] The overall structure of the model in this example is as follows figure 1 As shown, the model contains water storage tank 1 (simulating heart container 1) to simulate the heart as the source of inflow and outflow of blood, and water pump 2 transmits blood to funnels 3 and 4 containing liquid level sensors (radial artery blood pressure simulation container 3, head Venous blood pressure simulation container 4), according to the blood pressure of the radial artery and cephalic vein of the patient, the systolic pressure of the blood pressure is converted from the unit of mmHg to bar. Place the funnels 3 and 4 at different heights h1 and h2, respectively, in the funnels 3 and 4 When the liquid level sensor is lower than a certain value, it will drive the corresponding pump to act. When the liquid le...

Embodiment 2

[0061] Further, in Example 1, different mixing ratios are used to make silicone models with different elasticity, the size of the skin is 15*15*8mm, and the measurement is performed with a universal testing machine to select the skin that is closest to the skin parameters reported in the literature mold. A cross-sectional view of the fistula end-to-side coupling is shown in figure 2 As shown, the two main pipelines (92-radial artery simulated input tube; 93-capillary simulated input blood vessel) respectively flow to the radial artery inlet and capillary inlet of the fistula simulator 9 simulating the skin, in the model of the fistula simulator 9 , the cephalic vein simulated output tube 94 vein outlet is provided at the simulated skin, the cephalic vein 94 and the radial artery 92 form an arteriovenous fistula 95, the blood vessels are placed in the elastic silica gel of the simulated skin 91, and the whole artificial skin is placed in a 20*20* In the airtight iron box 100 ...

Embodiment 3

[0063] Further, the human body vessel model setting process in Example 2 is as follows image 3 As shown, the two water pipes are placed at a certain height before the model starts to work. This height is obtained after unit conversion based on the systolic pressure of the radial artery and cephalic vein before the fistula is constructed. The next two are to check the water storage tank 1 Whether the water in the water is enough to fill the water pipes in this model, whether the liquid level sensors 3 and 4 will alarm and trigger the pump to work, and then set the respective conduction times of the two diverter valves 5 and 6, which are determined by measuring Devices 7 and 8 measure the pressure and flow rate, and observe whether the waveform of the blood pressure is close to the normal waveform. If yes, proceed to the next step; otherwise, adjust the on-time until the Figure 4 results so far.

[0064] Then set the systolic blood pressure and diastolic blood pressure of the...

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Abstract

The invention provides an arteriovenous fistula in-vitro hemodynamic physical simulation model device. A simulation blood loop of the arteriovenous fistula in-vitro hemodynamic physical simulation model device comprises a simulation heart container, a radial artery blood pressure simulation container, a head vein blood pressure simulation container and a fistula simulator provided with a measuringdevice. The installation height of the radial artery blood pressure simulation container and the head vein blood pressure simulation container is greater than that of the simulation heart container;a fistula simulation cavity defined by elastic simulation skin is formed in the fistula simulator. The input end of the fistula simulation cavity is respectively communicated with the radial artery blood pressure simulation container and the head vein blood pressure simulation container, and the output end is communicated with the simulation heart container; when simulation is carried out, the fistula simulation cavity reaches the required deformation, simulation blood in the radial artery blood pressure simulation container and the head vein blood pressure simulation container flows back to the simulation heart container through the fistula simulation cavity, and a measuring device of the fistula simulator measures the pressure and the flow velocity of the blood flowing through the inputend and the output end. According to the invention, a set of stenosis-controllable stable blood vessel model can be established.

Description

technical field [0001] The invention relates to the technical field of simulation, in particular to an arteriovenous fistula hemodynamics physical simulation model device in vitro. Background technique [0002] With the development of China's economy, the acceleration of industrialization, urbanization, and behavioral and demographic changes have led to an increase in the morbidity and related mortality of chronic non-communicable diseases, among which chronic kidney disease (CKD) is the most prominent, and hemodialysis is the most important disease in patients with kidney disease. For long-term vascular access, autogenous arteriovenous fistula (AVF) should be the first choice. [0003] According to the literature at home and abroad, researchers at home and abroad are based on actual patients when conducting arteriovenous fistula research, but there is specificity among patients, and the data collected in the same period of internal fistula in different patients may cause in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G09B23/28A61B5/02
CPCG09B23/28A61B5/02028A61B5/02035
Inventor 罗堪黄炳法李建兴马莹黄靖陈炜赖智晨杨睿宁沈亮刘肖蔡聪
Owner FUJIAN UNIV OF TECH
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