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Compound for diagnosing polycystic ovarian syndrome and application

A polycystic ovary and compound technology, applied in the field of biomedicine, can solve problems such as high cost and complicated diagnosis

Active Publication Date: 2020-10-27
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] Aiming at the deficiencies of the prior art, the present invention aims to provide a compound for the diagnosis of polycystic ovary syndrome and its application, hoping to solve the clinical problems of complicated diagnosis and high cost in the prior art

Method used

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  • Compound for diagnosing polycystic ovarian syndrome and application
  • Compound for diagnosing polycystic ovarian syndrome and application
  • Compound for diagnosing polycystic ovarian syndrome and application

Examples

Experimental program
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Embodiment

[0028] The present invention takes the Rotterdam Consensus (2003 edition) as the standard for screening and including objects, and there are 51 participants in total, including 26 polycystic ovary syndrome patients and 25 healthy people.

[0029] Specifically, 10 mL of mid-urinary samples were collected from participants when they urinate for the first time in the morning and immediately stored in a -80°C refrigerator until analysis. For analysis, take out 50 μL of urine samples, add 200 μL of ice water and vortex for 2 minutes to fully mix, then sonicate for 2 minutes, and finally centrifuge at 13,000 rpm for 10 minutes at 4°C, take the supernatant in the injection vial and use UPLC-Q / TOF- MS for off-target metabolomics analysis. The data was collected by MassLynx V4.1 software, and imported into Progenesis QI V2.0 software for background noise removal, peak alignment and compound identification.

[0030] Then based on SIMCA V14.1 software, multivariate statistical analysis ...

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Abstract

The invention discloses a compound for diagnosing polycystic ovarian syndrome. The compound is one of androsterone glucosidic acid or sphingomyelin (d17: 1 / 24: 1), or a combination of androsterone glucosidic acid and sphingomyelin (d17: 1 / 24: 1). The method has the beneficial effects that the non-target metabonomics research on the polycystic ovarian syndrome urine is carried out through ultrahighpressure liquid phase tandem time-of-flight mass spectrometry, and androsterone glucosidic acid, sphingomyelin (d17: 1 / 24: 1) and the combination thereof are obtained, so that the compound has a relatively good diagnosis value on the polycystic ovarian syndrome. The purpose of simply and rapidly diagnosing the polycystic ovarian syndrome is achieved, and meanwhile the detection cost is reduced.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound for the diagnosis of polycystic ovary syndrome and its application. Background technique [0002] Polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder. [0003] According to epidemiology, its prevalence in women of childbearing age is 5% to 20%. The clinical features of polycystic ovary syndrome mainly include hyperandrogenism, menstrual disorders, and polycystic ovaries. In addition, patients with polycystic ovary syndrome are often accompanied by infertility, obesity, insulin resistance, type 2 diabetes or cardiovascular disease, etc., which seriously affect the lives of patients and their families, and bring a huge economic burden to the society. [0004] At present, there are three main methods for the analysis of polycystic ovary syndrome: [0005] 1. The Rotterdam Consensus (2003 version), which requires at least two of the followi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/86C07J1/0011C07F9/113
Inventor 谢智勇杨占东叶思敏
Owner SUN YAT SEN UNIV
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