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Hyaluronic acid fiber material and preparation method thereof

A technology of hyaluronic acid and fiber materials, applied in fiber processing, fiber chemical characteristics, rayon manufacturing, etc., can solve problems that limit the application of hyaluronic acid fiber materials

Active Publication Date: 2020-10-20
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN101775704B introduces a method for preparing pure hyaluronic acid nanofiber material, but because of the concentration of spinning solution and the strength of hyaluronic acid electrospun fiber, the application field of hyaluronic acid fiber material is limited

Method used

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  • Hyaluronic acid fiber material and preparation method thereof
  • Hyaluronic acid fiber material and preparation method thereof
  • Hyaluronic acid fiber material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Mix 0.4g of high-molecular methacrylylated hyaluronic acid (Mw=1.8 million Da), 0.2g of low-molecular-weight methacrylated hyaluronic acid (Mw=500,000Da), and 0.3g of polyethylene oxide Alkanes (Mw=1 million Da) were respectively dissolved in 5 ml of 70% formic acid-water solution. Mix the two solutions to a total of 10ml, add 0.1g of chitosan quaternary ammonium salt and 0.01g of photoinitiator I2595, stir evenly, and centrifugally defoam to obtain an electrospinning solution;

[0049] The electrospinning solution was placed in the liquid storage device of the electrospinning equipment (Japan MECC nano electrospinning machine, model: NANON-01A), and electrospinning was performed to obtain electrospun fibers. Among them, the electrospinning conditions are as follows: the inner diameter of the capillary needle is 0.6mm, the spinning voltage is 15kV, and the receiving distance between the spinneret and the receiving screen is 20cm;

[0050] The obtained electrospun fiber...

Embodiment 2- Embodiment 5

[0052] The difference between Examples 2-5 and Example 1 lies in the content and molecular weight of polyethylene oxide, chitosan quaternary ammonium salt, high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid. See Table 1 for detailed parameters. Other operating steps are the same as in Example 1.

Embodiment 6

[0054] The difference between Example 6 and Example 1 lies in the modification groups and cross-linking methods of the hyaluronic acid used. In Example 6, mercaptolated hyaluronic acid is used, and the cross-linking method adopts the method of curing and cross-linking by introducing oxygen. Concrete preparation steps are as follows:

[0055] Mix 0.4g of high-molecular mercapto-hyaluronic acid (Mw=1.8 million Da), 0.2g of low-molecular-weight mercapto-hyaluronic acid (Mw=500,000 Da), and 0.3g of polyethylene oxide (Mw=1 million Da) were respectively dissolved in 5 ml of 70% formic acid-water solution. Mix the two solutions to a total of 10ml, stir evenly, and centrifuge to defoam to obtain an electrospinning solution;

[0056] The electrospinning solution is placed in the liquid storage device of the electrospinning equipment, and electrospinning is performed to obtain electrospinning fibers. Among them, the electrospinning conditions are as follows: the inner diameter of the...

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Abstract

The invention provides a preparation method of a hyaluronic acid fiber material. The method comprises the following steps: dissolving hyaluronic acid and polyethylene oxide in an aqueous solution of formic acid to obtain an electrospinning solution; carrying out electrostatic spinning on the obtained electrospinning solution to obtain electrospun fibers; and crosslinking the obtained electrospun fibers to obtain the hyaluronic acid fiber material. Compared with the prior art, the high-molecular-weight and low-molecular-weight hyaluronic acid is reasonably proportioned, and the polyethylene oxide is added to prepare the electrospinning solution with higher hyaluronic acid content, so that the concentration of the hyaluronic acid is increased, the entanglement among the polymers is improved,the spinnability of the hyaluronic acid electrospinning solution is improved, and the strength and the flexibility of the fibers are increased; and the prepared fiber material can absorb redundant liquid of a human body or the outside, the softness and comfort of the material are improved, and simultaneously the protective capacity of the material can be improved.

Description

technical field [0001] The invention relates to the technical field of hyaluronic acid, in particular to a hyaluronic acid fiber material and a preparation method thereof. Background technique [0002] Medical protective clothing and masks refer to protective clothing used by medical personnel (doctors, nurses, public health personnel, cleaning personnel, etc.) and people entering specific medical and health areas (such as patients, hospital visitors, personnel entering infected areas, etc.) Clothing, its role is to isolate germs, harmful ultrafine dust, acid-base solutions, electromagnetic radiation, etc., to ensure the safety of personnel and keep the environment clean. Reusable protective clothing needs to be washed, high-temperature disinfection and other measures after use. Usually, the material is more comfortable, but the protective performance is poor. The washing and disinfection process will also increase a lot of manpower and water resource costs. The more common...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/18D01F8/16D01F1/10D01D5/00
CPCD01F8/18D01F8/16D01F1/103D01D5/003
Inventor 耿凤邵萌王静郭学平穆惠军
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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