A method and device for detecting abnormal circulating cells

A technology for abnormal cells and nuclei, which is applied in the field of detection of abnormal cells in circulation, can solve the problems of low reliability of subjectivity, low detection efficiency, high detection cost, etc., achieve high detection reliability and precision, avoid the influence of subjectivity, The effect of improving reliability and accuracy

Active Publication Date: 2022-06-24
ZHUHAI LIVZON CYNVENIO DIAGNOSTICS +1
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Problems solved by technology

However, the method for detecting CACs is based on the morphological information of CACs and combined with manual intervention to detect, confirm and count CACs. The detection is highly subjective and the reliability is not high, and due to the need for manual participation, the detection efficiency is low. High detection cost

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  • A method and device for detecting abnormal circulating cells
  • A method and device for detecting abnormal circulating cells
  • A method and device for detecting abnormal circulating cells

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[0057] In order to make the purposes, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only These are some embodiments of the present invention, but not all embodiments. The components of the embodiments of the invention generally described and illustrated in the drawings herein may be arranged and designed in a variety of different configurations. Thus, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without c...

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Abstract

The present invention provides a method and device for detecting abnormal circulating cells, wherein the method for detecting abnormal circulating cells includes: using image processing algorithms and morphological algorithms to analyze the nuclei contained in the dark field microscope images of multiple probe channels Segmentation and labeling are performed separately; darkfield microscopy images of multiple probe channels that label nuclei are input into a pre-built cycle abnormal cell detection model to obtain the staining contained in each labeled nucleus in the darkfield microscopy images of each probe channel Number of signals: For each labeled cell nucleus, based on the number of staining signals contained in the labeled cell nucleus in the obtained dark-field microscope image of each probe channel, determine whether the labeled cell nucleus belongs to a circulating abnormal cell. It can effectively improve the reliability of detecting circulating abnormal cells.

Description

technical field [0001] The present invention relates to the technical field of cell detection, and in particular, to a method and device for detecting Circulating Abnormal Cells (CACs). Background technique [0002] Circulating tumor cells (CTCs, Circulating Tumor Cells) are cells that shed from the primary tumor and form secondary tumors in distant organ sites during tumor metastasis. A large number of studies have shown that the number of CTCs in the blood can predict the progression of the disease and indicate the response of the tumor to chemotherapy drugs. Therefore, by collecting a certain amount of peripheral blood, CTCs are detected from the peripheral blood, and the changes in the content of CTCs in the blood are monitored. , which can be used to analyze the pathogenesis of tumors, evaluate the prognosis of patients, and understand the improvement of clinical conditions and drug resistance of patients after treatment. [0003] In recent years, circulating genetical...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06T7/00G06V20/69G06V10/80G06V10/82G06K9/62G06N3/04
CPCG06T7/0012G06T2207/10061G06V20/695G06V20/698G06N3/045G06F18/253G06T2207/10056G06T2207/20081G06T2207/20084G06T2207/30024C12Q1/68C12Q2563/173C12Q2565/601G06T5/002G06T7/11G06V20/70G06V2201/03G06V10/774G06T5/20G06T2207/20036G06T2207/30096
Inventor 范献军蓝兴杰叶莘张义李丛胜
Owner ZHUHAI LIVZON CYNVENIO DIAGNOSTICS
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