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Method for screening active ingredient groups in different processed products of curcuma wenyujin by bivariate correlation analysis method

A technology of active ingredients and processed products, which is applied in the field of bivariate correlation analysis to screen active ingredient groups in different processed products of Wenyujin, which can solve problems affecting clinical efficacy and clinical medication confusion

Inactive Publication Date: 2020-09-18
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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  • Application Information

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Problems solved by technology

However, since the three decoction pieces all have good effects of promoting blood circulation and removing blood stasis, the clinical

Method used

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  • Method for screening active ingredient groups in different processed products of curcuma wenyujin by bivariate correlation analysis method
  • Method for screening active ingredient groups in different processed products of curcuma wenyujin by bivariate correlation analysis method
  • Method for screening active ingredient groups in different processed products of curcuma wenyujin by bivariate correlation analysis method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Bivariate correlation analysis method to screen the active ingredient groups of traditional Chinese medicines of curcuma longa, zedoary and vinegar turmeric in different processed products of Wenyujin

[0029]To analyze and identify the blood components of turmeric, zedoary and vinegar zedoary plasma samples from different processed Wenyujin tablets, measure the efficacy indicators related to promoting blood circulation and removing blood stasis, and use the method of bivariate correlation analysis to screen the active components of traditional Chinese medicine.

[0030] 1. Experimental method

[0031] Measure the relative content change trend of three kinds of decoction pieces of turmeric, zedoary and vinegar zedoary into the blood in 0-12h (assay method sees embodiment 2), and the change process of drug efficacy indexes such as blood rheology in the same time (measurement method See embodiment 2 and 3), adopt SPSS 20.0 statistical software to carry out bivar...

Embodiment 2

[0070] Example 2 The changing trend of the relative content of three kinds of decoction pieces of turmeric, zedoary and vinegar zedoary in the blood in 0-12h, and the change process of the drug efficacy indexes such as blood rheology after administration of the three kinds of decoction pieces in 0-12h

[0071] In Example 1, the relative content change trend of three kinds of decoction pieces of turmeric, zedoary and vinegar zedoary in the blood in 0-12h, and the determination method of the change process of the drug efficacy indexes such as blood rheology after administration of the three kinds of decoction pieces in 0-12h as follows:

[0072] 1. Sample Preparation

[0073] 1.1 Reagent

[0074] The fresh rhizomes of Curcuma wenyujin were purchased from Tongming Wenyujin Professional Cooperative in Ruian City, Zhejiang Province, and were identified as fresh rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling by Professor Lu Tulin of Nanjing University of Traditional Chinese Medici...

Embodiment 3

[0102] Embodiment 3 pharmacodynamic experiment

[0103] Hemorheology is an emerging branch of biomechanics and biorheology. In the past 20 years, it has gradually developed into an independent discipline, mainly studying blood flow, cell deformation, the interaction between blood and blood vessels, the heart and A science of biochemical composition. The research content mainly includes more than 10 indicators such as whole blood viscosity, plasma viscosity, erythrocyte electrophoresis time, platelet electrophoresis time, fibrinogen determination, erythrocyte sedimentation rate and erythrocyte deformability. Literature research shows that the four coagulation items in the current research on blood stasis syndrome diseases include prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and other indicators It is closely related to the occurrence and development of blood stasis syndrome. Among them, PT is mainly used to reflect ...

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Abstract

Various traditional Chinese medicine components are adopted, and active components related to the medicine effect are found to be recognized difficulties in the field due to the characteristics of thesynergistic effect. The invention provides a method for screening active component groups in different processed products of curcuma wenyujin by using a bivariate correlation analysis method. The method comprises the following steps: measuring the change rule of blood entering components and drug effect indexes of different processed products of curcuma wenyujin along with time, and carrying outbivariate correlation analysis on component change and drug effect index change. The method can be used for obtaining three decoction pieces of rhizoma wenyujin longae, curcuma zedoary and vinegar-processed curcuma zedoary as well as active ingredients related to the efficacy of promoting blood circulation to remove blood stasis; although the curcuma zedoary has more blood-entering components in the three decoction pieces, the correlation with the drug effect is poorer than that of the raw curcuma zedoary and the vinegar curcuma zedoary, and the quantity of the blood-entering components in thevinegar curcuma zedoary is reduced, but the blood-entering components in the vinegar curcuma zedoary show extremely remarkable correlation with the drug effect index. According to the method providedby the invention, the relevance and similarities and differences between the blood-entering components of the three decoction pieces and the blood-activating and stasis-removing drug effects are defined, and a detailed material basis is provided for the research on the effect-taking and processing mechanism of traditional Chinese medicines, clinical practice guidance and the development of traditional Chinese medicine products.

Description

technical field [0001] The invention belongs to the technical field of screening active ingredient groups of traditional Chinese medicines, and in particular relates to a method for screening active ingredient groups in different processed products of curcuma curcuma by a bivariate correlation analysis method. Background technique [0002] Traditional Chinese medicine has various ingredients, wide range of effects, and exerts its own characteristics through synergistic effects. The overall composition ratio of different processed varieties of the same medicinal material has obvious changes. In addition to quantitative changes, some varieties can also produce new components before and after processing. Changes may be an important reason for the differences in their efficacy. However, it is even more difficult to find active ingredients related to drug efficacy from numerous chemical components and explain their relationship with drug efficacy improvement, which has become a b...

Claims

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Application Information

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IPC IPC(8): G01N33/15
CPCG01N33/15
Inventor 陆兔林毛春芹童黄锦郝敏顾薇王巧晗季德许金国苏联麟
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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