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Drug targeting HMGA2 gene, and application

A gene and drug technology, used in drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., can solve problems such as limited types and achieve the effect of inhibiting angiogenesis

Pending Publication Date: 2020-09-11
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the mechanism of hemangioma has not been thorough, and the types of therapeutic drugs available for treatment are also very limited

Method used

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  • Drug targeting HMGA2 gene, and application
  • Drug targeting HMGA2 gene, and application
  • Drug targeting HMGA2 gene, and application

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Experimental program
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Embodiment Construction

[0028] The technical solution of the present invention will be further described through specific implementation below.

[0029] The methods not specifically described in the following embodiments were carried out according to the methods recorded in "Experimental Technology of Biochemistry" and "Experimental Technology of Molecular Biology" or under the experimental operation suggested by commercial reagent suppliers.

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Abstract

The invention provides a drug targeting HMGA2 gene. The drug is characterized by comprising siRNA silencing the HMGA2 gene. According to the drug targeting the HMGA2 gene, and application in the invention, angiogenesis can be effectively inhibited by targeting the HMGA2 gene.

Description

technical field [0001] The invention relates to a drug targeting HMGA2 gene and its application, belonging to the field of biomedicine. Background technique [0002] Blood vessels play an important role throughout life, and are closely related to various physiological and pathological processes such as embryonic development, reproduction, and tumor development. Angiogenesis mainly includes two stages: angiogenesis and angiogenesis. Angiogenesis is the process by which new blood vessels are formed from vascular endothelial precursor cells differentiated from the mesoderm early in embryonic development; it is the mode by which major blood vessels are formed during embryonic development. Angiogenesis refers to the process of forming new blood vessels through the activation, proliferation, migration and extension of endothelial cells on the basis of existing blood vessels. Angiogenesis is jointly regulated by a variety of regulatory factors, and depends on the regulation of en...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7105A61P35/00C12Q1/6886
CPCA61K31/7105A61P35/00C12Q1/6886C12Q2600/178
Inventor 于昱王静鲁亚南冯睿曾照祥
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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