A bubble-driven annular micro-unit array assembly system and method

A technology for assembling systems and micro-units, which can be applied to biochemical equipment and methods, biochemical cleaning devices, and devices for human tubular structures, etc. performance and stability, low probability of failure, huge cost advantage

Active Publication Date: 2021-06-29
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the object of the present invention is to provide a bubble-driven annular micro-unit array assembly system and method, which can effectively solve the problems of complex system and poor flexibility in the micro-assembly process of microvascular two-dimensional annular units at the present stage.

Method used

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  • A bubble-driven annular micro-unit array assembly system and method
  • A bubble-driven annular micro-unit array assembly system and method
  • A bubble-driven annular micro-unit array assembly system and method

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Embodiment

[0034] The microvascular two-dimensional annular unit 5 used in this example has an outer diameter of 250 μm, an inner diameter of 100 μm, and a thickness of 40 μm. It is mixed with the culture solution and poured into the upper chamber of the culture dish 3. 75%, the length, width and height of the petri dish 3 are 15mm, 15mm and 18mm respectively, the wall thickness is 1mm, and the left air inlet pipe 2 and the right air inlet pipe 7 are in a normally closed state.

[0035] The specific operation process of a bubble-driven annular micro-unit array assembly method will be fully described below. figure 1 and Figure 2.

[0036] 1. Ensure that the liquid level of the culture solution in the culture dish 3 is 75% of the culture dish 3, and the left air inlet pipe 2 and the right air inlet pipe 7 are in a normally closed state, and the reversing valve 6 is in a straight state;

[0037] 2. Open the control valve of the left air inlet pipe 2, and pass compressed gas to the lower ch...

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Abstract

The invention discloses a bubble-driven circular micro-unit array assembly system and method. The left and right air pipes and reversing valves are used to alternately generate bubbles on the small hole array of the culture dish, and the rising bubbles in the culture solution promote uniform distribution. The microvascular two-dimensional ring unit at the bottom of the culture medium, the microvascular two-dimensional ring unit rises to the top of the culture medium under the push of air bubbles, stops the gas supply and falls, and some of them randomly fall onto the collection column. Repeat this process to realize the automatic assembly of microvessels ; The present invention does not release the microvascular two-dimensional annular unit, thus avoiding the influence of adhesion between microscopic objects, and because there is no large operating force, there is no possibility of damaging the microvascular, and the most important thing is that the entire operation The principle of the platform is simple, and the cost advantage is huge in comparison; because it can grasp two-dimensional ring units of microvessels with various diameters, and the simple structure brings extremely low possibility of failure, it has wide applicability and stability.

Description

technical field [0001] The invention belongs to the field of micro-nano operation and micro-assembly, and in particular relates to a bubble-driven annular micro-unit array assembly system and method. Background technique [0002] In recent years, tissue engineering is experiencing an unprecedented period of rapid development. Many relevant scientists and medical practitioners use this technology to construct artificial tissues or organs to replace damaged, deteriorating or dead tissues and organs in the human body or animals, which brings great benefits to human health and is an important component of future biological high-tech part. However, due to the lack of blood circulation in artificial tissues, many artificial tissues or organs that have been cultivated to a certain scale cannot obtain nutrients or oxygen in the culture medium in time and lose or die. This has become an important factor hindering the development of tissue engineering. Therefore, artificial blood ve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00C12M1/04C12M1/00A61F2/06
CPCA61F2/06A61F2240/001C12M21/08C12M23/34C12M29/14
Inventor 刘晓明李玉洋黄强新井健生
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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