Mobile nanosecond pulse ablation instrument

Abstract

The invention discloses a mobile nanosecond pulse ablation instrument. The instrument comprises a cabinet body provided with universal wheels at the bottom, and is characterized in that a pulse generation system for generating nanosecond pulses is arranged inside the cabinet body, and a pulse output system for delivering the nanosecond pulses to a load is arranged outside the cabinet body; the pulse output system comprises a rocker arm fixed on the cabinet body and an electrode needle junction box fixed with the tail end of the rocker arm, and an electrode needle is arranged on the electrode needle junction box; a transmission line transformer is arranged in the rocker arm; one end of the transmission line transformer is electrically connected with the output end of the pulse transmissionsystem, and the other end is electrically connected with the electrode needle junction box. The ablation instrument can be directly used in the nanosecond pulse electric field ablation process, and has the advantages of convenient use, compact structure and good application prospect.

Description

technical field [0001] The invention belongs to the technical field of pulse ablation, and in particular relates to a mobile nanosecond pulse ablation instrument applicable to tumor tissue ablation. Background technique [0002] Cancer is currently the main factor threatening human life, clinically, surgical resection is considered to be the only way to treat certain malignant tumors. With the development of the field of bioelectromagnetics, pulsed electric field ablation technology, as a non-thermal ablation method, has attracted extensive attention from the academic community. Based on irreversible electroporation of the cell membrane system, assisted by molecular biology and medical imaging, the pulsed electric field ablation technology delivers high-frequency, high-voltage short pulses to the tumor tissue to place the tumor tissue in a strong electric field. When persistent micropores appear on the cell membrane At this time, the internal substances of the cells flow ou...

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Problems solved by technology

[0004] The nanoknife currently used in clinical pulsed electric field ablation generates pulse widths in the microsecond range. During clinical use, due to the long pulse width, the continuous injection of energy will cause current leakage to the muscle tissue near the ablation area. During treatment, muscle action potentials are induced and muscle tremors occur, causing the electrode needles to move and fall off during treatment, which affects the ablation effect and may cause mechanical damage to surrounding tissues

[0005] In order to avoid the occurrence of the above situation, it is usually necessary to inject a large amount of muscle relaxants and anesthetize the patient before treatment, which is risky

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