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Optical fiber bundle super-resolution imaging method and system, computer equipment and storage medium

A super-resolution imaging and imaging system technology, applied in computing, optics, image enhancement, etc., can solve problems such as the inability to break through the diffraction limit of the imaging system, and achieve the effect of breaking through the diffraction limit

Active Publication Date: 2020-07-28
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above method only realizes the fusion and splicing of multiple images, and cannot break through the diffraction limit of existing imaging systems.

Method used

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  • Optical fiber bundle super-resolution imaging method and system, computer equipment and storage medium
  • Optical fiber bundle super-resolution imaging method and system, computer equipment and storage medium
  • Optical fiber bundle super-resolution imaging method and system, computer equipment and storage medium

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Embodiment Construction

[0048] In order to make the purpose, technical solution and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present application, and are not intended to limit the present application.

[0049] In one embodiment, combined with figure 1 , providing a fiber bundle super-resolution imaging method, the method comprising:

[0050] Step S01, acquiring N fluorescence images of samples irradiated with different structured light via fiber optic bundles;

[0051] Here, the optical fiber bundle contains multiple optical fibers. Due to the loss of information between the optical fibers, an illumination light field with a honeycomb structure will be generated on the sample surface, causing the fluorescent protein molecules on the sample surface to emit fluorescence, w...

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Abstract

The invention discloses an optical fiber bundle super-resolution imaging method and system, computer equipment and a storage medium, and belongs to the field of optical fiber bundle imaging, and the method comprises the steps: obtaining a plurality of sample fluorescence images irradiated by different structured light through an optical fiber bundle; calculating and obtaining a wide-field image; calculating and obtaining a low-resolution sample image; calculating an optical fiber bundle structured light irradiation image corresponding to each sample fluorescence image; calculating a covarianceimage and an optical transfer function thereof; and calculating a reconstructed super-resolution sample image. According to the invention, the honeycomb structure of the optical fiber bundle image can be removed, and the super-resolution concept is applied to the optical fiber bundle imaging, so that the high-resolution imaging is realized.

Description

technical field [0001] The invention belongs to the field of optical fiber bundle imaging, in particular to an optical fiber bundle super-resolution imaging method, system, computer equipment and storage medium. Background technique [0002] Fiber optic bundles have played an important role in endoscopic imaging, providing cellular-level visualization for the diagnosis of a range of diseases in vivo. Typically, fiber optic bundles contain a large number of fiber cores (typically up to 30,000) that simultaneously transmit and acquire optical signals. However, the distance between the cores (i.e., the cladding) will cause a noticeable honeycomb pattern on the acquired image, thereby degrading the image quality and imaging resolution. [0003] At present, the commonly used method is to use Gaussian filtering (such as the paper "Pixelation effect removal from fiber bundle probe based optical coherence tomography imaging") or linear interpolation (such as the fiber bundle image ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T3/40G06T5/50A61B1/00G02B23/24
CPCA61B1/00165G02B23/2407G06T3/4076G06T5/50G06T2207/10068G06T2207/20216
Inventor 刘家林杨西斌徐宝腾周伟熊大曦
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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