Artificial blood pump in vitro simulated circulatory system

Abstract

The invention discloses an artificial blood pump in vitro simulated circulation system, comprising a test bench and a left ventricle simulator, an aorta simulator, a vein simulator, a left atrium simulator and an artificial blood pump assembled in the test bench; The device includes a closed cavity with adjustable volume; the left ventricle simulator, the aorta simulator, the vein simulator, and the left atrium simulator are connected in sequence through pipelines, and connected end to end to form a simulated cycle; the left ventricle simulator is connected to the pipeline of the aorta simulator An aortic valve simulator is installed, and a mitral valve simulator is installed on the pipeline from the left atrium simulator to the left ventricle simulator to realize the one-way flow of liquid in the simulated circulation; the input port of the artificial blood pump is equipped with a three-way valve, and the three-way valve The two input ends of the valve are respectively connected with the left ventricle simulator and the left atrium simulator, and the output port is connected with the aorta simulator, and the liquid is pumped from the left ventricle simulator or the left atrium simulator into the aorta simulator. The volume of the left ventricle simulator can be adjusted to simulate the changes of ventricular volume and pressure.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to an artificial blood pump extracorporeal simulated circulation system. Background technique [0002] The blood pump emerged as a temporary or permanent substitute for the living heart. Its appearance provides a new treatment method for heart failure that is ineffective in drug and surgical treatment or transitional support before heart transplantation, and provides a new way for the treatment of heart failure. direction of development. The in vitro simulated circulatory system mainly simulates physiological signals such as peripheral resistance of blood vessels, vascular compliance, inertia and pressure flow of the human body, and provides a test platform for the newly developed VAD. Before the in vivo experiment of VAD, the performance test must be carried out in the in vitro simulated circulation system. The in vitro simulation experiment based on MCA can conduct a comprehensive ...

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Problems solved by technology

However, when simulating the diastolic process of the ventricle, the diastolic process cannot be adjusted, and the amount of gas entering the simulated chamber of the left ventricle cannot be accurately controlled each time, so that it is impossible to accurately simulate the volume change process of the actual human left ventricle during exercise.

Huang Penghui from Soochow University in the article "In Vitro Experimental Research on the Pulsating Flow Mode of Complete Magnetic Suspension Centrifugal Blood Pump", the silicon diaphragm is pushed by a linear motor, and the deformation of the silicone diaphragm simulates the volume change of the left ventricular cavity. When simulating the left ventricular During diastole, the passive relaxation process is uncertain, so the volume change of the left ventricle during diastole cannot be accurately simulated

At the same time, there will be negative pressure in the left ventricle, which is inconsistent with the actual situation, and the diaphragm is prone to fatigue and has a short life span

Chinese patent 201510778366.6 discloses a piston-type ventricular simulator for in vitro simulated circulatory system, which uses a driving mechanism to push the piston to simulate the beating of the left ventricle, but the structure does not consider the alignment of the piston, cavity and drive shaft. There is no seal between the rigid piston and the cavity of the invention, and the leakage leads to limitations in the pressure and volume simulation of the ventricular simulator, which cannot accurately simulate the ventricular action of the actual human body

[0004] In summary, none of the above-mentioned existing papers or inventions can accurately simulate the process of ventricular volume and pressure changes throughout the entire cardiac cycle of the actual human body, and cannot take into account both the stepless adjustment of aortic compliance and the active and accurate control of the left ventricular simulated chamber action

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