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Marker for predicting prognosis of cancer patients and application of marker

A marker and cancer technology, applied in the field of biomedicine, can solve the problems of reducing total mortality and low accuracy

Active Publication Date: 2020-06-30
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many large-scale clinical trials have been conducted over the past few decades to validate lung cancer screening methods, including chest X-ray examination, sputum cytology, and chest CT, none of them have significantly reduced overall mortality. Rate
In addition, currently commonly used clinical tumor markers such as CEA, NSE, Cyfra2l-1, etc. have low accuracy in early diagnosis and prognosis

Method used

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  • Marker for predicting prognosis of cancer patients and application of marker
  • Marker for predicting prognosis of cancer patients and application of marker
  • Marker for predicting prognosis of cancer patients and application of marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1 Screening of differentially expressed genes associated with survival of endometrial cancer patients

[0064] 1. Dataset

[0065] The sequencing data of 333 endometrial cancer patients published in nature in the TCGA database were used as the analysis data set (Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013)).

[0066] 2. Analysis method

[0067] There are 52 patients with advanced (stage III, IV) endometrial adenocarcinoma in the TCGA database. The grouping strategy considers that the cases with an overall survival of more than 5 years are high-survival cases. There are 11 cases in total, and the overall survival is less than 2 years. The patients who died were low survival cases, with a total of 4 cases. The correlation R language package (edgeR) was used to obtain the differentially expressed genes between long-survival patients and short-survival patients of endometrial adenocarcinoma (the absolute value of the Pearson correlation coefficient wit...

Embodiment 2

[0074] Example 2 Correlation between FAM65B gene and survival of patients with lung adenocarcinoma

[0075] 1. Dataset

[0076] Lung Adenocarcinoma (TCGA, PanCancer Atlas) was used for analysis.

[0077] 2. Analysis method

[0078] Survival analysis and ROC curve analysis were carried out on the differentially expressed gene FAM65B of high and low survival patients with endometrial cancer screened in patients with lung adenocarcinoma. Value) ≥ 0.55 can be used as a model to predict the length of patient survival.

[0079] 3. Results

[0080] The results of the patient survival analysis were image 3 As shown, the survival period of lung adenocarcinoma patients with high expression of FAM65B gene is longer, and the survival period of lung adenocarcinoma patients with low expression of FAM65B gene is shorter, the difference is statistically significant (P=0.0012), and the prognosis of patients with high expression of FAM65B gene is obvious Better than patients with low FAM6...

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Abstract

The invention discloses a marker for predicting prognosis of cancer patients and an application of the marker, and the cancer comprises endometrial cancer and lung adenocarcinoma. The marker is FAM65B. The invention also discloses a product for predicting prognosis of cancer patients, and the product can achieve the purpose of predicting prognosis of cancer patients by detecting the expression amount of the FAM65B.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a marker for predicting the prognosis of cancer patients and its application. Background technique [0002] Endometrial cancer is one of the three common malignant tumors of the female reproductive system, accounting for about 7% of female cancers and 20-30% of female reproductive system malignant tumors. In recent years, the incidence of endometrial cancer has been on the rise worldwide, and it is younger (Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002[J]. CA Cancer J Clin, 2005, 55(2):74-108). [0003] With the in-depth study of traditional markers and the continuous discovery of new markers, immunohistochemistry plays an increasingly important role in the pathological diagnosis and differential diagnosis of endometrial cancer (Wu Huanwen, Liang Zhiyong, Zhang Hui, Liu Tonghua. Uterus Research progress on immunohistochemical markers of endometrial carcinoma. Diagno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 钱海利张颖王婷马飞林晨李春晓赵振国郭建宾
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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