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Vanadyl and vanadate for use in reducing stress -induced metabolic derangement

A metabolic disorder and stress technology, applied in metabolic diseases, medical preparations containing active ingredients, active ingredients of heavy metals, etc., can solve problems such as non-optimal nursing standards and hypoglycemia

Pending Publication Date: 2020-06-26
CFM PHARM HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] From the issues outlined above regarding the development of hyperglycemia in individuals exposed to stress, such as surgical patients, and regarding the risk of subsequent hypoglycemia due to too strict control of glucose levels in surgical patients, it is clear that the Current standard of care for treating hyperglycemia in trauma-causing patients is far from optimal

Method used

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  • Vanadyl and vanadate for use in reducing stress -induced metabolic derangement
  • Vanadyl and vanadate for use in reducing stress -induced metabolic derangement
  • Vanadyl and vanadate for use in reducing stress -induced metabolic derangement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Embodiment 1

[0120] Effect of BMOV on Stress-Induced Hyperglycemia in Normal Healthy Rats - In Vivo Evaluation BMOV Prevents or Reduces Hyperglycemia sugar capacity.

[0121] A stress-induced hyperglycemia model was developed which does not include any surgical procedure for inducing hyperglycemia in an individual and which does not require administration of any composition by infusion to induce hyperglycemia in an individual. Stress is induced by infusion of epinephrine into the individual such that the individual is subjected to the stress in a time-controlled manner.

[0122] Purpose: The purpose of the exemplary study was to show the beneficial effects of BMOV on stress and / or trauma-induced hyperglycemia in healthy individuals.

[0123] Methods: Male Wistar rats (body weight 300g to 400g) were included in the study.

[0124] 1) Series 1: Rats (n=13; 4-5 / group) were infused with epinephrine via the jugular vein for 180 minutes at a rate of 0.1 μg / kg / min, 0.3 μg / kg / min or 1 μg / kg / m...

Embodiment 2

[0174] Exemplary experiments have shown that pretreatment of individuals with BMOV prior to the stress to which the individual is subjected / exposed results in Reduce and / or prevent hyperglycemia during exposure of the body to stress.

[0175] test article

[0176] Name: Bis(malto)vanadyl (BMOV)

[0177] BMOVs were dissolved in phosphate-buffered saline.

[0178] General Test System Parameters

[0179] animals need

[0180] Twelve healthy male Wistar rats weighing 300 to 400 g were purchased from the Animal House of the University of Pécs (Hungary) and included in the exemplary study.

[0181] feed

[0182] Housing: Animals were housed in cages complying with the size recommendations in the latest guide for the care and use of laboratory animals DHEW (NIH) and EU guideline 63 / 2010. The bedding placed under the cage was changed at least 3 times a week. The temperature of the animal room was controlled with a 12 hour light / dark cycle with 7 am to 7 pm light and kept cle...

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PUM

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Abstract

The current invention relates to the use of a physiologically acceptable organic and / or inorganic vanadium compound or complex, such as for example bis(maltolato)oxovanadium (BMOV) in the prevention or amelioration of stress-induced metabolic derangement in a subject. More in particular, the invention relates to a physiologically acceptable organic and / or inorganic vanadium compound or complex foruse in the amelioration of hyperglycemia in a subject suffering from stress such as elicited by a trauma, wherein the physiologically acceptable organic and / or inorganic vanadium compound or complexis administered to said subject before the trauma is inflicted to the subject. Furthermore, the invention relates to a physiologically acceptable organic and / or inorganic vanadium compound or complexfor use in the prevention of hyperglycemia in a subject having a trauma, wherein the physiologically acceptable organic and / or inorganic vanadium compound or complex is administered to said subject before the subject has the trauma. In one embodiment a physiologically acceptable organic and / or inorganic vanadium compound or complex is administered to a human subject 2 to 24 hours before said humansubject is subjected to surgery, for the prevention or amelioration of hyperglycemia elicited by a trauma related to the surgery. It is part of the invention that the physiologically acceptable organic and / or inorganic vanadium compound or complex are a source of vanadyl or vanadate in a patient to whom such compound or complex is administered.

Description

[0001] field of invention [0002] The present invention relates to the use of physiologically acceptable organic and / or inorganic vanadium compounds or complexes, such as bis(malto)vanadium oxide (BMOV), for preventing or ameliorating stress-induced metabolic disturbances in an individual. More specifically, the present invention relates to physiologically acceptable organic and / or inorganic vanadium compounds or complexes for ameliorating hyperglycemia in individuals subjected to stress, such as that caused by trauma, wherein the The subject is administered a physiologically acceptable organic and / or inorganic vanadium compound or complex. Furthermore, the present invention relates to physiologically acceptable organic and / or inorganic vanadium compounds or complexes for use in the prevention of hyperglycemia in traumatized individuals, wherein a physiologically acceptable organic vanadium compound or complex is administered to said individual prior to trauma. and / or inorgani...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/28A61K31/351A61K33/24A61P3/10
CPCA61K31/28A61K31/351A61K33/24A61P3/06A61K31/555
Inventor 亨德里克斯·詹·科尼利斯·梅杰林克约瑟夫斯·约翰尼斯·德吉姆彼列赫拉姆·昌格尔
Owner CFM PHARM HLDG BV
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