Micro-nano particle nondestructive carrying method and device based on controllable micro-scale bubbles

A micro-nano particle, micro-scale technology, applied in enzymology/microbiology devices, tissue cell/virus culture devices, biochemical cleaning devices, etc. , to achieve a reliable release effect

Active Publication Date: 2020-06-23
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current transport of micro-nano particles based on capillary force mainly relies on liquid droplets as the means of operation. Liquid droplets can only operate on hydrophilic particles, so there are certain restrictions on the surface properties of the objects to be operated.
For example, patent CN 103009387B discloses a droplet micromanipulation manipulator based on capillary adhesion, which is simple and easy to operate, and can be used to operate tiny objects of any shape in the air, but it cannot be used in liquid environments such as petri dishes, so it cannot Manipulating biological samples such as cells
At the same time it is not possible to manipulate particles with different surface properties (hydrophobic / hydrophilic) without changing the device settings

Method used

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  • Micro-nano particle nondestructive carrying method and device based on controllable micro-scale bubbles
  • Micro-nano particle nondestructive carrying method and device based on controllable micro-scale bubbles
  • Micro-nano particle nondestructive carrying method and device based on controllable micro-scale bubbles

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Experimental program
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Effect test

Embodiment 1

[0042] Combine below figure 1 , figure 2 Description of this embodiment

[0043] A non-destructive transport device for micro-nano particles includes an optical microscope platform 1, a No. 1 fixed connecting plate 2 fixed on the scientific microscope platform 1, and a three-degree-of-freedom precision mobile platform 3 fixed on the No. 1 fixed connecting plate 2 . The capillary 7 for micro-nano operation is fixed on the three-degree-of-freedom precision mobile platform 3 through the second fixed connection plate 4 , and is connected with the air pressure generator and the controller 5 through the connecting pipe 6 . Both the petri dish 9 and the disc-shaped piezoelectric transducer 14 are fixedly connected to the operation base plate 10 . The operation bottom plate 10 is placed on the optical microscope platform 1 and is located below the micro-nano operation capillary 7 . The disk-shaped piezoelectric transducer 14 is connected to the signal generator 13 through a line. ...

Embodiment 2

[0055] Combine below figure 1 , image 3 Description of this embodiment

[0056] A non-destructive transport method for micro-nano particles with micro-force sensing and a device for realizing the method (abbreviated as micro-nano particle transport method and device), including an optical microscope platform 1 and a No. 1 fixed connection plate fixed on the scientific microscope platform 1 2. The three-degree-of-freedom precision mobile platform 3 fixed on the No. 1 fixed connecting plate 2 . The capillary 7 for micro-nano operation is fixed on the three-degree-of-freedom precision mobile platform 3 through the second fixed connection plate 4 , and is connected with the air pressure generator and the controller 5 through the connecting pipe 6 . Both the petri dish 9 and the disc-shaped piezoelectric transducer 14 are fixedly connected to the operation base plate 10 . The operation bottom plate 10 is placed on the optical microscope platform 1 and is located below the micro...

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Abstract

The invention discloses a micro-nano particle nondestructive carrying method and device based on controllable micro-scale bubbles. The method comprises the following steps that an air pressure generator and a controller switch are turned on, and the controllable micro-scale bubbles are generated at the tail end of a micro-nano operation capillary tube and defined as operation bubbles; a three-degree-of-freedom precision moving platform is utilized for driving the micro-nano operation capillary tube connected with the air pressure generator and a controller, and the operation bubbles are movedto the position above an operated object; for the operation object with the hydrophilic surface, under assistance of a sound field, the operated object is picked up through capillary force; for the operation object with the hydrophobic surface, the capillary force is directly utilized for picking up; and the micro-nano operation capillary tube is moved to the to-be-released position, and micro-nano particles are released through the capillary force for releasing the bubbles. According to the method, the controllable micro-scale bubbles are utilized as an end effector, under assistance participation of the sound field, the micro-nano particles with different surface properties can be grabbed, carried and released, and deformation of the controllable micro-scale bubbles is observed in real time.

Description

technical field [0001] The invention relates to the technical field of micro-nano particle operation, in particular to a micro-nano particle non-destructive transport method with micro-force sensing based on air bubbles and a device for realizing the method. Background technique [0002] Micromanipulation usually refers to various manipulations and controls on micron-scale objects, and is an essential means to realize the assembly and testing of micro-electromechanical systems (MEMS). Its core is to transport various micro-nano particles. With the continuous demand for functional integration and miniaturization of microsystem products and the rapid development of micro-nano technology. The size of the operation objects that need to be processed in the micro-operation technology is continuously decreasing and the types are increasing. At present, the commonly used micro-nano manipulation methods can be mainly divided into mechanical clamping and vacuum adsorption. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B25J15/00B25J9/00C12M3/00C12M1/36C12M1/22
CPCB25J9/00B25J15/00B25J15/0023C12M23/10C12M23/16C12M41/00
Inventor 刘吉晓周一笛严珺嘉朱童郭士杰李铁军
Owner HEBEI UNIV OF TECH
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