Application of substance for detecting MIP gene mutation in diagnosing giant panda cataracts

A technique for giant pandas, cataracts, applied in the field of veterinary medicine

Active Publication Date: 2020-06-19
北京动物园
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, detailed mechanisms based on specific mutations still hide behind phenotypic heterogeneity and require further investigation

Method used

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  • Application of substance for detecting MIP gene mutation in diagnosing giant panda cataracts
  • Application of substance for detecting MIP gene mutation in diagnosing giant panda cataracts
  • Application of substance for detecting MIP gene mutation in diagnosing giant panda cataracts

Examples

Experimental program
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Effect test

Embodiment 1

[0055] Example 1. Discovery of Gene Mutations Related to Giant Panda Cataracts

[0056] 1. Materials

[0057] Cataract giant panda: Ji Ni, born in 1993, from Beijing Zoo, female, captive breeding. Cataract incidence in 2015, such as figure 1 shown. Unilateral eye disease is characterized by cortical cataract in the early stage, lens opacity around the cortex, which is feathery opacity. Vision loss.

[0058] In addition, 5 giant pandas from Chongqing Zoo, Chengdu Zoo and Beijing Zoo were selected as controls. The information of each panda is as follows:

[0059] panda name year of birth source disease state gender Ya dick Year 1999 Chongqing Zoo A healthy giant panda without cataracts female freezing point 2000 Chengdu Zoo Health without cataracts male Yaya 1990 Chengdu Zoo Health without cataracts female Lele 1986 Beijing Zoo cataract patients female Ginny 1993 Beijing Zoo cataract patients ...

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Abstract

The invention discloses an application of a substance for detecting MIP gene mutation in diagnosing giant panda cataracts. Gene mutation associated with the giant panda cataracts is found, nucleotideat a 686th position of the MIP gene is mutated from G into A, so that a 229th position of an encoded MIP protein is mutated from a serine residue to an asparagine residue, the mutation is present in giant panda Jini with the cataracts, and the mutation is not present in remaining giant pandas, so that the results show that the mutation can be used to diagnose the giant panda cataracts or to evaluate the risk of suffering from the cataracts.

Description

technical field [0001] The invention relates to the application of a substance for detecting MIP gene mutation in the diagnosis of giant panda cataract in the field of animal medicine. Background technique [0002] Most cataracts are related to aging, environmental factors or genetic factors. About one-third of cataracts have a distinct genetic component, some due to disruption of normal lens development and some due to mutations in crystallin itself or other proteins required for normal lens physiology, including blockade of oxidative stress response pathways. Cumulative reactions to oxidative damage can also progressively destroy the lens, either leading to the accumulation of pigment or the aggregation of crystal proteins, which are the main components of lens clarity and refraction. However, there are genetic mutations that affect crystallins, as well as mutations that affect structural proteins of the connexin and precursor myelin family, connexins, or stress response ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883G01N33/6893C12Q2600/156G01N2800/166G01N2800/50G01N2333/4703
Inventor 由玉岩柏超王伟贾婷刘学锋尹彦强普天春卢岩夏茂华陈玉村王利勤修云芳杜洋马涛刘彦晖张成林李晓光
Owner 北京动物园
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