Application of substance for detecting MIP gene mutation in diagnosing giant panda cataracts

Abstract

The invention discloses an application of a substance for detecting MIP gene mutation in diagnosing giant panda cataracts. Gene mutation associated with the giant panda cataracts is found, nucleotideat a 686th position of the MIP gene is mutated from G into A, so that a 229th position of an encoded MIP protein is mutated from a serine residue to an asparagine residue, the mutation is present in giant panda Jini with the cataracts, and the mutation is not present in remaining giant pandas, so that the results show that the mutation can be used to diagnose the giant panda cataracts or to evaluate the risk of suffering from the cataracts.

Description

technical field [0001] The invention relates to the application of a substance for detecting MIP gene mutation in the diagnosis of giant panda cataract in the field of animal medicine. Background technique [0002] Most cataracts are related to aging, environmental factors or genetic factors. About one-third of cataracts have a distinct genetic component, some due to disruption of normal lens development and some due to mutations in crystallin itself or other proteins required for normal lens physiology, including blockade of oxidative stress response pathways. Cumulative reactions to oxidative damage can also progressively destroy the lens, either leading to the accumulation of pigment or the aggregation of crystal proteins, which are the main components of lens clarity and refraction. However, there are genetic mutations that affect crystallins, as well as mutations that affect structural proteins of the connexin and precursor myelin family, connexins, or stress response ...

AI Technical Summary

Problems solved by technology

However, detailed mechanisms based on specific mutations still hide behind phenotypic heterogeneity and require further investigation

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