Polymer compound capable of being quickly dissolved or dispersed in water-containing solvent as well as preparation method and application of polymer compound

A polymer and composite technology, applied in the field of medical polymers, can solve the problems of easy mutual adhesion, loss of rapid dissolution, increase in use cost, etc., to achieve the effect of convenient use and improvement of entanglement

Active Publication Date: 2020-06-16
FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as the patent CN 109675122 A states in the first article of the summary of the invention "the present invention provides a solid hydrogel composite that can be dissolved in water by stirring", the instant-dissolving thermotropic compound disclosed in the patent CN 109675122 A The rapid dissolution of hydrogel composites in water still needs to be achieved by vortex shaking or magnetic stirring, which requires specific mechanical equipment assistance in practical applications, which increases the cost of use and is not convenient enough
In addition, the crystalline solid in the compound described in the above patent is an organic compound, and coordination interaction with polymer molecules cannot occur, and a relatively large content is needed to barely maintain the shape of the compound at room temperature. In the environment of 30°C, the composite solids are easy to stick to each other and lose the property of rapid dissolution

Method used

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  • Polymer compound capable of being quickly dissolved or dispersed in water-containing solvent as well as preparation method and application of polymer compound
  • Polymer compound capable of being quickly dissolved or dispersed in water-containing solvent as well as preparation method and application of polymer compound
  • Polymer compound capable of being quickly dissolved or dispersed in water-containing solvent as well as preparation method and application of polymer compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A polymer complex 80P20CaCl that dissolves rapidly in aqueous solvents 2 , which consists of 1.6g of PLA-PEG-PLA with a molecular weight of 1750-1500-1750 and 0.4g of calcium chloride.

[0042] Step (1): 1.6 g of PLA-PEG-PLA with a molecular weight of 1750-1500-1750 was placed in water, and magnetically stirred at 4°C for 24 hours to form a solution with a polymer concentration of 20 wt %;

[0043] Step (2): Dissolving 0.4g of calcium chloride in water to form a calcium chloride solution;

[0044] Step (3): Add the calcium chloride solution in step (2) to the polymer solution in step (1), dilute with water until the polymer concentration is 15wt%, mix well and put it in a water bath at 37°C for 2 hours to form gel;

[0045] Step (4): The gel obtained in step (3) was frozen at -80° C. for 4 hours, then vacuum-dried in a freeze dryer for 12 hours to obtain a polymer complex that quickly dissolved in an aqueous solvent.

[0046] The characteristics of polymer complexes ...

Embodiment 2

[0048] A complex of polymers 90P10CaCl that dissolves rapidly in aqueous solvents 2 -1, which consists of 0.9g of PLGA-PEG-PLGA with a molecular weight of 1500-1000-1500, 0.9g of PLGA-PEG-PLGA with a molecular weight of 1250-1500-1250, and 0.2g of calcium chloride.

[0049] Step (1): 0.9 g of block copolymers with two molecular weights were placed in water together, and magnetically stirred for 24 hours at 4° C. to form a solution with a polymer concentration of 20 wt %;

[0050] Step (2): Dissolving 0.2g of calcium chloride in water to form a calcium chloride solution;

[0051] Step (3): Add the calcium chloride solution in step (2) to the polymer solution in step (1), dilute with water until the polymer concentration is 4.5wt%, place it at 20°C and stir for 0.5h, then stir while stirring Raise the temperature to 40°C, and continue to stir for 0.5h to obtain a compound solution;

[0052] Step (4): The solution obtained in step (3) was frozen at -20°C for 12 hours, and then ...

Embodiment 3

[0055] Polymer Complex 90P10CaCl Dissolves Rapidly in Aqueous Solvents 2 -2, its composition is 1.8g of PLGA-PEG-PLGA with a molecular weight of 1950-1500-1950, and 0.2g of calcium chloride.

[0056] Step (1): 1.8 g of PLGA-PEG-PLGA with a molecular weight of 1950-1500-1950 was placed in water, and magnetically stirred at 4° C. for 24 hours to form a solution with a polymer concentration of 20 wt %;

[0057] Step (2): Dissolving 0.2g of calcium chloride in water to form a calcium chloride solution;

[0058] Step (3): Add the calcium chloride solution in step (2) to the polymer solution in step (1), dilute with water until the polymer concentration is 10wt%, place at 20°C and stir for 0.5h, then heat up while stirring to 40°C, continue to stir for 0.5h to obtain a compound solution;

[0059] Step (4): The solution obtained in step (3) was frozen at -20° C. for 12 hours, then vacuum-dried in a freeze dryer for 24 hours to obtain a complex that quickly dissolved in an aqueous s...

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Abstract

The invention relates to a polymer compound capable of being quickly dissolved or dispersed in a water-containing solvent as well as a preparation method and application of the polymer compound. The compound is a solid prepared by compounding a dispersing agent and a water-soluble polymer, is stable in property and convenient to store, and can be quickly dispersed in the water-containing solvent to form a solution. The solution can be injected, has a thermotropic gelation property, is convenient to use, and can be widely applied to the fields of medicine and the like.

Description

technical field [0001] The invention relates to the technical field of medical macromolecules, in particular to a macromolecular compound that is rapidly dissolved or dispersed in water, and a preparation method and application thereof. Background technique [0002] Medical polymers often need to be dissolved in aqueous solvents. However, the dissolution of polymers is usually a relatively slow process, which often requires long-term stirring, heating, cooling and other treatments, which obviously limits the application prospects of such polymers. [0003] Taking injectable thermotropic hydrogel as an example, it is usually a special material formed by dissolving amphiphilic block copolymers in water. It is usually a free-flowing micellar solution at low temperature, and it can be transformed into a gelatinous solution when the temperature rises. gelatinous. The thermally induced gelation property of this reverse phase endows it with broad application prospects in the fiel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L87/00C08K3/16C08K3/30C08K5/098C08K13/02C08K5/17C08K3/32A61K8/90A61K39/39A61K47/34A61L15/26A61L15/62A61L31/06A61L31/14A61P37/04A61Q19/00
CPCC08K3/16C08K3/30C08K13/02C08K5/098C08K5/175C08L87/005A61K47/34A61L31/06A61L31/14A61K8/90A61Q19/00A61L15/26A61L15/62A61K39/39A61P37/04C08K2003/162C08K2003/3045C08K2003/325C08L2205/025A61K2039/555A61K2800/10C08K3/32C08L101/14A61K8/19A61K8/27A61K47/02C08G81/00C08G2230/00C08K2003/3072C08K2201/018
Inventor 丁建东唐敬玉曹丁凌格俞麟
Owner FUDAN UNIV
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