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A method for identifying miRNA-sponge interaction pairs

A recognition method and an interactive pairing technology, applied in the field of gene recognition, can solve the problems of low computational efficiency and high time complexity, and achieve the effect of appropriate time complexity

Active Publication Date: 2021-05-14
UNIV OF ELECTRONICS SCI & TECH OF CHINA +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] The object of the present invention is to, aiming at the deficiencies in the above-mentioned prior art, provide a kind of recognition method, device, equipment and storage medium of miRNA sponge interaction pair, to improve the non-linear correlation relationship between identification miRNA sponge in the prior art When the calculation efficiency is low and the time complexity is high, it is not suitable for the identification of miRNA sponge interaction network with large-scale data

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  • A method for identifying miRNA-sponge interaction pairs
  • A method for identifying miRNA-sponge interaction pairs
  • A method for identifying miRNA-sponge interaction pairs

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Embodiment Construction

[0033]In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments.

[0034] figure 1 A schematic flow chart of the identification method for miRNA-sponge interaction pairs provided in an embodiment of the present application, wherein the execution subject of the identification method for miRNA-sponge interaction pairs in this application is a terminal device capable of executing programming languages ​​such as R, Python, and C++, for example , may be a laptop computer, a desktop computer, a server, etc., and is not limited here.

[0035] Such as figure 1 As shown, the identification methods of miRNA sponge interacti...

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Abstract

The invention provides a method for identifying miRNA sponge interaction pairs, and relates to the technical field of gene identification. The method for identifying the miRNA-sponge interaction pair includes: obtaining the sponge gene expression matrix, the target gene expression matrix and the miRNA expression matrix of the sample. And calculate the miRNA sponge interaction pair recognition parameters of the sponge gene of the matching sample and the target gene. If the identification parameters of the miRNA-sponge interaction pair between the sponge gene of the matching sample and the target gene meet the preset conditions, it is confirmed that the sponge gene and the target gene of the matching sample are miRNA-sponge interaction pairs. Due to the fusion of heterogeneous data sources in the calculation of miRNA-sponge interaction identification parameters, and when determining the miRNA-sponge interaction pair, it is based on the miRNA competition mechanism to measure the competition strength between miRNA sponges to identify the non-linearity between miRNA sponges Correlation relationship, and then determine miRNA sponge interaction pairs, realize the appropriate time complexity, and can identify the non-linear correlation relationship between miRNA sponges.

Description

technical field [0001] The invention relates to the technical field of gene identification, in particular to a method, device, equipment and storage medium for identifying miRNA-sponge interaction pairs. Background technique [0002] MicroRNA (MiRNA, miRNA) is a class of small non-coding RNA molecules with an endogenous length of about 22 nucleotides. It inhibits post-transcriptional gene expression by regulating protein-coding gene mRNA (Messenger RNA). miRNA plays an important regulatory role in biological processes such as cell differentiation, cell proliferation, cell growth, cell migration, apoptosis and cancer. Different gene transcripts sharing MREs (miRNA response elements) compete with each other to regulate gene expression. These competing transcripts are collectively referred to as ceRNA or miRNA sponges, including protein-coding mRNAs, long noncoding RNAs (lncRNAs), pseudogene transcripts (pseudogenes), and circular RNAs (circRNAs). The network is called ceRNA ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B20/00G16B40/00
CPCG16B20/00G16B40/00
Inventor 张俊鹏饶妮妮王光斌
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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