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Use of red semblance extract for improving the gene expression of hyaluronic acid synthase

A technology of gene expression and red sorghum, applied in the direction of drug combination, function of food ingredients, food ingredients containing natural extracts, etc. Reduces wrinkles and improves skin barrier function

Active Publication Date: 2021-10-08
TCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the above, in order to improve the problem of skin becoming fragile and sensitive due to the damage of keratinocytes and the decrease of water retention capacity, a new product that can effectively make keratinocytes secrete more moisturizing factors, maintain the arrangement of keratinocytes, and maintain keratin Layer structure is complete, in order to enhance the composition of the skin barrier function, it is really necessary

Method used

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  • Use of red semblance extract for improving the gene expression of hyaluronic acid synthase
  • Use of red semblance extract for improving the gene expression of hyaluronic acid synthase
  • Use of red semblance extract for improving the gene expression of hyaluronic acid synthase

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Experimental program
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Effect test

Embodiment 1

[0018] Embodiment 1 The preparation method of the red saffron extract of the present invention

[0019] Trifolium pratense (Trifolium pratense) is a perennial herbaceous plant of the genus Trifolium in the Fabaceae family. It is native to Europe and northern Asia. It was introduced into Taiwan in the early days as a forage grass and soil and water conservation plant, and it is also occasionally planted for ornamental purposes. The stem of the red samosa is an upright or oblique ascending stem, about 15-65 cm long, with branches and scattered hairs; the leaves are three compound leaves, ovate, obovate or oblong, about 1.5-3 cm long , 0.5-2 cm wide; the flowers are pink and densely grown, arranged in a flower head. Red Shucao has the effect of clearing away heat, relieving cough and reducing swelling.

[0020] In one embodiment of the present invention, the whole plant of Red Shucao is cleaned, and the washed whole plant of Red Shucao is mixed with an extraction solvent of wate...

Embodiment 2

[0021] Example 2 Efficacy of the red saffron extract of the present invention in regulating gene expression in keratinocytes

[0022] The present invention uses human primary epidermal keratinocytes (HPEK) to regulate TGM1 gene, KRT1 gene, KRT10 gene, KRT14 gene, APQ3 gene, FLG gene, SMAD1 gene, GBA gene, Analysis of HAS2 gene and HAS3 gene expression. The human primary skin keratinocytes were purchased from CELLnTEC (Switzerland) No. HPEK-50, and the cells were cultured in serum-free keratinocyte medium (keratinocyte-SFM) (Gibco, No. #17005042, U.S.), and contained 5%CO 2 cultured in a 37°C cell culture incubator.

[0023] Human primary keratinocytes were divided into two groups: (1) the experimental group adding 0.0039 mg / mL of the red sage extract of the present invention and (2) the control group containing only the cell culture medium for 24 hours, and then the keratinocytes were After the cells were recovered with cell lysate (RBbuffer, purchased from Geanaid Company,...

Embodiment 3

[0028] Example 3 The effect of the red saffron extract of the present invention on increasing the water content of human skin and reducing wrinkles

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Abstract

The present invention relates to the field of plant extracts, in particular to the use of a Trichosanthes extract for enhancing the gene expression of hyaluronic acid synthase. The S. japonica extract of the present invention is obtained by extracting S. japonicus with a solvent of water, alcohol, or a mixture of alcohol and water, which can be used to increase the gene expression of uric acid synthase, increase skin moisture content and reduce skin wrinkles, In order to make the skin form more moisturizing factors and maintain the integrity of the stratum corneum structure to improve the skin barrier function.

Description

technical field [0001] The present invention relates to the field of plant extracts, in particular to the use of red saffron extracts for improving the gene expression of hyaluronic acid synthase. Background technique [0002] The epidermis is the outermost layer of the skin. From the outside to the inside, it consists of the stratum corneum, granular layer, spinous layer, and basal layer. The epidermis is mainly formed by continuous upward differentiation of undifferentiated cylindrical keratinocytes in the basal layer. The process is called keratinization. The water content in corneocytes is high. As the cells metabolize and differentiate upward, the shape of corneocytes will gradually become flat, and the nucleus and organelles will begin to degenerate and shrink, and dead cells without nuclei and organelles will form in the stratum corneum. The main function of the epidermis is to keep the skin water and form a skin barrier to resist various external injuries. The outer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K36/48A61P17/16A61P39/06A23L33/105
CPCA23V2002/00A61K36/48A23L33/105A61P17/16A61P39/06A23V2200/318A23V2200/302A23V2250/21
Inventor 林咏翔
Owner TCI CO LTD
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