Acanthopanax trifoliatus polysaccharide, preparation method thereof, and application of Acanthopanax trifoliatus polysaccharide in preparation of antitumor drugs
The technology of anti-tumor drug and white succulent polysaccharide is applied in the direction of anti-tumor drug, drug combination, pharmaceutical formulation, etc., which can solve the problem of no research report on the anti-cancer activity of macromolecular compounds, and achieve the effect of strong proliferation inhibitory activity.
Inactive Publication Date: 2020-03-27
南京赛尔健生物技术有限公司
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[0005] Studies have found that a variety of small molecular compounds in Bougainvillea have antican
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The invention discloses an Acanthopanax trifoliatus polysaccharide, a preparation method thereof, and an application of the Acanthopanax trifoliatus polysaccharide in the preparation of antitumor drugs. The Acanthopanax trifoliatus polysaccharide has a high total sugar content (90% or above), and is a precipitate formed by precipitating a water extract, obtained by removing a 66% ethanol precipitate from Acanthopanax trifoliatus stems, with 80% ethanol. In-vitro antitumor activity test results show that the Acanthopanax trifoliatus polysaccharide has extremely strong proliferation inhibition activity on human esophageal cancer cells and human ovarian cancer cells, so that the Acanthopanax trifoliatus polysaccharide has a prospect of being developed into anti-human esophageal cancer and anti-human ovarian cancer drugs.
Description
technical field [0001] The invention relates to bougainvillea polysaccharides, in particular to a bougainvillea polysaccharide, a preparation method and an application for preparing antitumor drugs. Background technique [0002] Ovarian cancer is the second most common female reproductive malignancy, and its mortality rate ranks first among gynecological tumors. Worldwide, approximately 200,000 people are diagnosed with ovarian cancer each year and 125,000 people die from the disease. Due to the relatively hidden incidence of ovarian cancer and the lack of effective screening and early diagnosis methods, 70% to 80% of patients are already at an advanced stage when they see a doctor. The treatment effect and prognosis are extremely poor, and the 5-year survival rate is less than 20%. [0003] Esophageal cancer is a malignant tumor that occurs on the esophagus. The etiology is unknown so far. It is generally believed that it is related to factors such as poor food, alcohol co...
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Login to view more IPC IPC(8): C08B37/00A61K31/715A61P35/00A61P1/00A61P15/08A61K36/254
CPCA61K31/715A61K36/254A61P1/00A61P15/08A61P35/00C08B37/00C08B37/0003
Inventor 于海涛杨晓旭
Owner 南京赛尔健生物技术有限公司
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