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Application of caspofungin in preparation of medicine for treating ischemia/reperfusion injury

A technology for reperfusion injury and caspofungin, which is used in drug combinations, cardiovascular system diseases, cyclic peptide components, etc., to reduce myocardial ischemic infarct size, highlight substantial characteristics, and reduce myocardial cell death.

Pending Publication Date: 2020-03-13
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] Caspofungin was launched in 2001. It has good inhibitory activity against Candida, Aspergillus, etc. It is used for invasive Candida and aspergillosis that cannot be tolerated or other antifungal drugs are not effective, but whether it has anti-myocardial The effect of ischemia / reperfusion injury has not been reported

Method used

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  • Application of caspofungin in preparation of medicine for treating ischemia/reperfusion injury
  • Application of caspofungin in preparation of medicine for treating ischemia/reperfusion injury
  • Application of caspofungin in preparation of medicine for treating ischemia/reperfusion injury

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Embodiment Construction

[0023] The following experiments further illustrate its drug activity.

[0024] Animal experiment: the protective effect of caspofungin on rat model of myocardial ischemia-reperfusion injury.

[0025] Implemented drugs: commercially available.

[0026] Caspofungin was dissolved in saline.

[0027] Experimental animals: healthy male SD rats with a body weight of 250-300 g. The experimental animals were fed for one week in an environment with a temperature of 25° C., a relative humidity of 60%, free access to drinking water, and regular and quantitative quantities, and then administered intraperitoneally according to the requirements of each group in the experiment.

[0028] Rat myocardial ischemia model establishment method: SPF grade Sprague-Dawley rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium (0.1mL / kg), fixed on the mouse board, and the hair on the neck and left chest was removed . Connect the rat limbs to the electrocardiogram machine, a...

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Abstract

The invention relates to an application of caspofungin in preparation of a medicine for treating ischemia / reperfusion injury. The caspofungin is used for treating ischemia / reperfusion injury, particularly myocardial tissue ischemia, and more particularly has a protective effect on myocardial ischemia / reperfusion, so that the myocardial ischemia / reperfusion injury can be remarkably reduced.

Description

technical field [0001] The invention relates to the application of caspofungin in the preparation of medicines for treating ischemia / reperfusion injury, and belongs to the field of biomedicine. Background technique [0002] Myocardial infarction is mainly caused by cardiac ischemia. It is predicted that by 2020, there will be more than 9 million myocardial infarction patients nationwide. If there is no timely reperfusion or no collateral circulation, cardiomyocytes will be irreversibly damaged and replaced by fibrous scar tissue with almost no contractile function. Therefore, reperfusion therapy is a common means to limit the infarct size and improve the cardiac function after ischemia; damage". However, reperfusion therapy is often accompanied by some myocardial injury, causing pathophysiological lesions. Further injury caused by reperfusion after ischemia is called I / R injury. Myocardial I / R injury involves multiple mechanisms such as oxidative stress, calcium overload...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61P9/10
CPCA61K38/12A61P9/10
Inventor 罗秀菊唐励静田静彭紫梅涂画黄钰琳刘斌彭军
Owner CENT SOUTH UNIV
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