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A method for constructing directional and ordered pores inside elastic hydrogels

A technology of internal orientation and hydrogel, which is applied in the field of construction of internal directional and ordered pores of elastic hydrogels, can solve the problems of difficulty in controlling the orientation degree of hydrogel pores and uneven pore size, and achieve wide application value and development Foreground, regular arrangement of channels, and low preparation cost

Active Publication Date: 2021-08-31
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a method for constructing oriented and ordered pores inside elastic hydrogels, so as to overcome the defects of difficult control of the orientation degree of hydrogel pores and non-uniform pore sizes in the prior art

Method used

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  • A method for constructing directional and ordered pores inside elastic hydrogels
  • A method for constructing directional and ordered pores inside elastic hydrogels
  • A method for constructing directional and ordered pores inside elastic hydrogels

Examples

Experimental program
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Effect test

Embodiment 1

[0026] 5g of TPU particles were added to a mixed solution of 7.1mL DMF and 11.3mL THF, and stirred at 60°C for 8h to form a spinning solution with good fluidity (the concentration of the spinning solution was 23wt%). The spinning solution is spun at a voltage of 15kV, the spinning rate is 0.5mL / h, and the drum speed is 800rpm to obtain an electrospun TPU fiber membrane, which is stretched 2 times, and the TPU fiber membrane before and after stretching Scanning electron microscope picture as figure 2 As shown, it can be seen that the average diameter of the unstretched fibers is 1.26 μm, and the average diameter of the fibers in the orientation direction of the fibers stretched twice is 0.873 μm.

[0027] Use the 100μm silicone mat produced by 3M Group to cut out two rectangular grooves of 6cm×2cm, paste one rectangular groove on a smooth glass plate, stick the stretched 2 times TPU fiber film on the rectangular groove, and then stick the other rectangular groove After the gr...

Embodiment 2

[0031] According to Example 1, the mass of the acrylic acid monomer was changed to 0.41 g (the molar ratio of acrylamide and acrylic acid was 100:2), and the rest were the same as in Example 1 to obtain a hydrogel with internally oriented and ordered pores. The pore structure of the hydrogel is the same as that of Example 1, and the mechanical properties are similar to those of Example 1.

Embodiment 3

[0033] According to Example 1, the mass of acrylic acid monomer was changed to 0.10 g (the molar ratio of acrylamide and acrylic acid was 200:1), and the rest were the same as in Example 1 to obtain a hydrogel with internally oriented and ordered pores. The pore structure of the hydrogel is the same as that of Example 1, and the mechanical properties are similar to those of Example 1.

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Abstract

The invention relates to a method for constructing directional and ordered channels inside an elastic hydrogel. The method comprises: adding a crosslinking agent and an initiator to a mixed solution of acrylamide and acrylic acid to obtain a gel prepolymerization solution; fixing stretched orientated thermoplastic polyurethane (TPU) fibers in a mold, pouring the gel prepolymerization solution Put it into the mold, embed the TPU fiber with vacuum assistance, then cure it with UV light, and then dissolve the fiber. The preparation process of the method is simple and efficient, and the preparation cost is low. The obtained hydrogel has good mechanical strength, and the pores are arranged regularly. It can be used in the fields of tissue engineering, material transmission, biosensing and the like, and has relatively wide application value and development prospect.

Description

technical field [0001] The invention belongs to the field of hydrogel preparation, in particular to a method for constructing directional and ordered channels inside elastic hydrogels. Background technique [0002] Hydrogel is a kind of hydrophilic polymer that can swell in water and retain a large amount of water without dissolving. It has a three-dimensional network structure. Biological soft tissue is essentially a kind of hydrogel with special functions, and these functions are reflected in its interior with many ordered pore structures for rapid material transport. Therefore, the construction of ordered pores in artificially synthesized hydrogels can partially simulate some special functions of biological soft tissues and serve as carriers for material transmission. [0003] Gel inherently has disordered nanoscale micropores between molecular chains, and the pore size, mechanical and swelling properties can be adjusted by adjusting the ratio of monomers and crosslinkin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/56C08F220/06C08F222/38C08J3/075C08J9/26
CPCC08F220/56C08J3/075C08J9/26C08J2333/26C08J2475/04C08F220/06C08F222/385
Inventor 王继强孙胜童武培怡
Owner DONGHUA UNIV
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