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Application of compound palosuran to prevention and treatment of diseases of skeletal muscle atrophy

A skeletal muscle and compound technology, applied in the field of biomedicine, to improve the secretory function of skeletal muscle, increase the cross-sectional area, and achieve the effect of safe and reliable drugs

Active Publication Date: 2020-02-07
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, there is currently no targeted drug with better efficacy in the treatment of obesity / diabetic skeletal muscle atrophy

Method used

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  • Application of compound palosuran to prevention and treatment of diseases of skeletal muscle atrophy
  • Application of compound palosuran to prevention and treatment of diseases of skeletal muscle atrophy
  • Application of compound palosuran to prevention and treatment of diseases of skeletal muscle atrophy

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1. The preparation of compound

[0050] The compound palosuran is obtained by chemical synthesis, and the LCMS purity is >99.99%. The compound powder was dissolved in physiological saline to prepare a 10 mg / mL solution, which was then stored at -80°C for later use. Dilute with normal saline to the corresponding concentration when used.

Embodiment 2

[0051] Example 2. Effects of Compounds on Skeletal Muscle Factors in Obese C57BL / 6J Mice Induced by High Fat

[0052] Significance: Muscle can regulate other distant organs in autocrine, paracrine and endocrine ways, and these muscle-derived secreted factors are defined as "myokines". Myokine is mainly divided into two categories: myokine that promotes muscle growth and myokine that inhibits muscle growth. Myokine reflects the secretory function of skeletal muscle.

[0053] Experimental method: Male C57BL / 6J mice, weighing 17-20g, were fed with high-fat diet, with no restriction on water. C57BL / 6J mice of the same age were used as a normal control group, weighing 17-20 g, fed with complete nutritional feed, without water restriction. Monitor body weight weekly. After the high-fat-fed mice were 10 g heavier than the normal control group, the mice in the obese group were randomly divided into two groups: the high-fat control group and the palosuran-administered group. The pal...

Embodiment 3

[0055] Example 3. Effects of compounds on muscle tension in KKAy mice

[0056] Significance: The strength of skeletal muscle is the main index reflecting the contraction function of skeletal muscle, which is closely related to the degree of atrophy of skeletal muscle. The pull test of skeletal muscle reflects the maximum force of animal skeletal muscle.

[0057] Experimental method: In this experiment, 9-week-old male KKAy mice, weighing 30-40 grams, were fed with special feed for KKAy mice, with no restriction on water, and were randomly divided into model group and compound administration group. The control group was 9-week-old C57BL / 6J mice with a body weight of 15-20 grams, which were fed with ordinary feed and not limited to water. The compound group was given 10 mg / kg palosuran by intraperitoneal injection for 32 days. The control group and model group were given the same dose of normal saline. Check your weight weekly. The detection of animal forelimb skeletal muscl...

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Abstract

The invention relates to the fields of biology and medical care, in particular to an application of a compound palosuran ( CAS No.:540769-28-6 ) to preparation of medicines for preventing, relieving and / or treating skeletal muscle atrophy, myopathy and muscle prevention and treatment of diseases of skeletal muscle atrophy skeleton complications. The compound disclosed by the invention has notableeffects of improving skeletal muscle force, enlarging cross cutting area of skeletal muscle fiber bundles, and improving secretory function of skeletal muscle. The compound is novel in function, easyin synthesis and low in consumption, and has good application and development prospects.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to the use of compound palosuran in the preparation of prevention, alleviation and / or treatment of skeletal muscle atrophy, myopathy and musculoskeletal complications caused by genetics, malnutrition, obesity, metabolic syndrome, diabetes and related diseases in the application. Background technique [0002] Clinically, "the volume of skeletal muscle has decreased compared with the previous state of the same age or its own muscle, resulting in localized or generalized muscle volume reduction that can be distinguished by naked eyes or imaging, or a decrease in the number or diameter of muscle fibers observed under a microscope" Defined as muscular atrophy [Lu He, Yuan Yun. Diagnosis and differential diagnosis of muscular atrophy [J]. Chinese Journal of Practical Internal Medicine, 2009, (02): 97-100.]. Muscle fiber diameter <35 μm in adult males and <28 μm in adult females c...

Claims

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Application Information

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IPC IPC(8): A61K31/4709A61P19/08A61P21/00A61P3/10A61P3/04A61P3/00A61P3/06
CPCA61K31/4709A61P19/08A61P21/00A61P3/10A61P3/04A61P3/00A61P3/06
Inventor 杜冠华杨秀颖陈熙强桂芬殷琳贾伟华王诺琪张莉侯碧玉
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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