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Polyurethane microporous foaming film for persistent antibacterial central venous catheters and preparation method thereof

A polyurethane film and microcellular foaming technology, applied in catheters and other directions, can solve the problems of central venous cannula detachment, bacterial invasion, and poor bacteriostatic effect, so as to prolong the sustained release period, enhance the bacteriostatic effect, and avoid excessive release. quick effect

Inactive Publication Date: 2020-01-10
SHANDONG INOV POLYURETHANE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies in the prior art, the object of the present invention is to provide a polyurethane microporous foam film for central venous tubes with persistent antibacterial effect, the surface of which has a micro-rough structure, which avoids the existing central venous sleeves from being easily removed from the large veins of the human body. Falling off, causing the risk of other complications caused by bacterial invasion, and has a long-term antibacterial effect, which solves the problem of poor continuous antibacterial effect of existing materials; the invention also provides its preparation method

Method used

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  • Polyurethane microporous foaming film for persistent antibacterial central venous catheters and preparation method thereof
  • Polyurethane microporous foaming film for persistent antibacterial central venous catheters and preparation method thereof
  • Polyurethane microporous foaming film for persistent antibacterial central venous catheters and preparation method thereof

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Effect test

Embodiment 1

[0030] A kind of polyurethane microporous foam film for central venous tube with persistent antibacterial effect, the preparation method is as follows:

[0031] (1) In terms of parts by mass, 100 parts of PTMEG-500, 0.01 part of nano silicon dioxide and 0.01 part of bismuth octadecanoate catalyst are added to the reactor A equipped with mechanical stirring and thermometer, and the set temperature is 90°C; add 44 parts of MDI to reactor B, set the temperature to 65°C; add 13 parts of BDO to reactor C, set the temperature to 55°C;

[0032] (2) When the temperature of each reactor is stable, the raw material components in reactor A / B / C are mixed and injected into the twin-screw reactor through the high-speed rotating mixing head through the infusion system with precise metering, and the mixed material is in the twin-screw barrel Uniform reaction, the polyurethane film with a thickness of 50 μm and a width of 0.5 m is made by extruding a cast film head;

[0033] (3) Place two ves...

Embodiment 2

[0035] A kind of polyurethane microporous foam film for central venous tube with persistent antibacterial effect, the preparation method is as follows:

[0036] (1) In parts by mass, 100 parts of PPG-2000, 0.1 part of nano-calcium carbonate and 0.02 part of bismuth octadecanoate catalyst are added to reactor A equipped with mechanical stirring and thermometer, and the setting temperature is 100 ℃; Add 57 parts of HMDI into Reactor B, set the temperature at 50°C; Add 24 parts of HQEE into Reactor C, set the temperature at 50°C;

[0037] (2) When the temperature of each reactor is stable, the raw material components in reactor A / B / C are mixed and injected into the twin-screw reactor through the high-speed rotating mixing head through the infusion system with precise metering, and the mixed material is in the twin-screw barrel Uniform reaction, the polyurethane film with thickness of 100μm and width of 0.5m is made by extrusion cast film head;

[0038] (3) In the supercritical b...

Embodiment 3

[0040] A kind of polyurethane microporous foam film for central venous tube with persistent antibacterial effect, the preparation method is as follows:

[0041] (1) In terms of parts by mass, 50 parts of PTMEG-4000, 50 parts of PPG-4000, 0.5 parts of silicon dioxide, 0.5 nanometer calcium carbonate and 0.015 parts of bismuth octadecanoate catalysts are added to the In the reactor A of the thermometer, set the temperature to 90°C; add 60 parts of MDI to the reactor B, and set the temperature to 65°C; add 20 parts of BDO to the reactor C, and set the temperature to 55°C;

[0042] (2) When the temperature of each reactor is stable, the raw material components in reactor A / B / C are mixed and injected into the twin-screw reactor through the high-speed rotating mixing head through the infusion system with precise metering, and the mixed material is in the twin-screw barrel Uniform reaction, the polyurethane film with a thickness of 200μm and a width of 0.5m is made by extruding a cas...

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Abstract

The invention relates to the technical field of polyurethane elastomers, in particular to a polyurethane microporous foaming film for persistent antibacterial central venous catheters and a preparation method of the polyurethane microporous foaming film. The polyurethane microporous foaming film for persistent antibacterial central venous catheters is obtained by modifying polyurethane film with an active medium and a bacteriostatic agent under the action of a supercritical foaming gas; wherein the dosage of the active medium is 0.1-5% of the mass amount of the polyurethane film; the use amount of the bacteriostatic agent is 0.1-5% of the mass amount of the polyurethane film; the polyurethane film is prepared from the following raw materials: a polyether polyol, a diisocyanate, a small molecular chain extender, a nano filler and a catalyst. According to the polyurethane microporous foaming film for persistent antibacterial central venous catheters, the surface of the polyurethane microporous foaming film is of a fine rough structure, the situation that an existing central venous catheter is prone to falling off from the great vein of human body is avoided, the long-acting antibacterial effect is achieved, and the problem that an existing material is poor in continuous antibacterial effect is solved; the invention also provides a preparation method of the polyurethane microporous foaming film.

Description

technical field [0001] The invention relates to the technical field of polyurethane elastomers, in particular to a polyurethane microporous foaming film for a central venous tube with persistent antibacterial effect and a preparation method thereof. Background technique [0002] The application of supercritical technology covers the fields of microcellular foaming, modification, extraction, drying and spraying, and has developed rapidly at home and abroad. Among them, supercritical microcellular foaming technology can prepare foaming materials with a cell size of less than 100 μm, which has been widely used in industry, electronics, medical and other fields. In addition, its strong dissolution and penetration ability makes it have good mass transfer effect , has also been applied to the modification inside the microporous structure. [0003] Central venous catheter (CVC) is a kind of intravascular tube. Clinical use of central venous catheter can be used to measure central ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/12C08J7/12C08J7/14C08J5/18C08L75/08C08K3/36C08K3/26C08G18/66C08G18/48C08G18/32C08G18/76C08G18/75A61L29/06A61L29/16A61L29/14
CPCA61L29/06A61L29/146A61L29/16A61L2300/404A61L2300/604C08G18/3206C08G18/3215C08G18/4808C08G18/4825C08G18/4854C08G18/6674C08G18/758C08G18/7671C08J5/18C08J7/12C08J7/14C08J2375/08C08K3/36C08K2003/265C08K2201/011C08L75/04
Inventor 陈淑海王丹张宁刘凯良贺宽宽
Owner SHANDONG INOV POLYURETHANE
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