A step-by-step drug delivery device

Abstract

The present invention proposes a step-by-step drug delivery device, comprising: a load-bearing assembly, a drug delivery catheter, a wire tube, a threaded rod, a nut, a signal recorder and a connecting rod; wherein, a nut is sleeved in the middle of the threaded rod, and the threaded rod The lower end of the threaded rod contacts the lower inner wall of the bearing assembly, the upper end of the threaded rod penetrates the upper part of the bearing assembly, and the upper end of the threaded rod is provided with a driving structure; the bearing assembly is also provided with a stopper for limiting the rotation of the nut, so that when the threaded rod rotates , to realize the up and down movement of the nut; when the nut moves up and down, it drives the drug delivery catheter to move up and down. Through this device, the stepping of the drug delivery catheter can be realized, so that a larger area can be administered, and in this solution, an electrode wire for detecting neuronal signals is attached to the drug delivery catheter, thereby realizing drug delivery It is integrated with signal detection, and can detect the area where the drug is administered in a targeted manner, and the signal acquisition is more timely and targeted, so that the acquired signal is more accurate.

Description

technical field [0001] The invention relates to the field of biomedical experiment devices, in particular to a step-by-step drug delivery device. Background technique [0002] In biological experiments, there are many methods of drug administration for experimental animals, such as intraperitoneal injection, intravenous injection, and gavage. However, for the study of brain nerves and brain diseases, the above administration methods have serious deficiencies: [0003] First, some drugs cannot pass through the blood-brain barrier and fail to achieve the expected effect; [0004] Second, the dosage is small, generally a few microliters or even less. [0005] The traditional way of drug administration for experimental animals is limited in targeting neurological and brain diseases. [0006] For this reason, a central nervous system administration method has also been developed, which is mostly used for the response of target nuclei or brain regions to drugs. At present, the ...

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Problems solved by technology

[0007] However, because the catheter is fixed in this way, it can only be administered to a fixed position, and one such device cannot be administered to multiple positions, and cannot achieve more comprehensive drug delivery; and the current method takes up Excessive volume, after implantation of catheters in the brain it is no longer possible to embed microelectrode arrays for signal recording, which makes accurate recording of neuronal electrical signals impossible, for example after acute drug administration

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