Platelet inhibition rate calculation method based on thromboelastography

Abstract

The invention discloses a platelet inhibition rate calculation method based on thromboelastography. The method comprises the steps that a blood sample is detected to acquire a thromboelastogram, wherein the thromboelastogram comprises the maximum coagulation intensity MAt curve, the minimum coagulation intensity MAf curve and the platelet coagulation curve f(t) of a coagulated blood sample; the coordinate axis of the curves of the thromboelastogram is transformed, the X axis is translated to the position of the symmetry axis of the three curves; the amplitude value of the detected coagulationintensity and the coagulation time value are integrated; the integral coagulation strength DIt of the maximum coagulation intensity MAt curve, the integral coagulation intensity DIf of the minimum coagulation intensity MAf curve and the integral coagulation intensity of the coagulation curve f(t) are calculated respectively; and the platelet inhibition rate BPI=(1-(DI-DIf) / (DIt-DIf))*100% is calculated. The acquired evaluation results are more accurate and can accurately reflect the actual state of platelet inhibition after the use of platelet inhibitory drugs.

Description

technical field [0001] The invention relates to the technical field of platelet inhibition rate, in particular to a calculation method for platelet inhibition rate based on thromboelastography. Background technique [0002] Thromboelastogram (TEG) is an index that reflects the dynamic changes of blood coagulation (including the formation speed of fibrin, the dissolution state, the solidity of the coagulation, and the elasticity). Therefore, the factors that affect the thromboelastogram mainly include: the aggregation of red blood cells state, the rigidity of red blood cells, the speed of blood coagulation, the activity of fibrinolytic system and so on. figure 1 Shown is the theoretical curve of thromboelastography, which reflects the different stages of measured blood coagulation. The X-axis in the figure is time (T / Min), and the Y-axis is the intensity amplitude of blood coagulation (mm). The main indicators of thromboelastography are: : [0003] 1. The reaction time (R) ...

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Problems solved by technology

[0018] 2. After the use of anti-platelet drugs, the coagulation curve will not only increase slowly, but also prolong the R value (ie, coagulation latency time), indicating that the pro-coagulant effect of platelets also lags behind under the action of inhibitory drugs. The point cannot be reflected in the above algorithm;

[0019] Therefore, the calculation method of the above-mentioned platelet inhibition rate has defects, and cannot reflect the actual state of platelet inhibition after the use of platelet inhibitory drugs, and there will be deviations in clinical observation and judgment of the drug effect of patients

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