Super-resolution and microscopic analysis MOT (magnetic-optical tweezer) device

A microscopic analysis and super-resolution technology, applied in the microscopic field, can solve problems such as the inability to realize combined manipulation, and achieve the effect of improving operational accuracy and stability and precise control

Inactive Publication Date: 2019-12-20
武汉铢寸科技有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, the above-mentioned combinations cannot realize the combined manipulation of the same molecule by magnetic tweezers and optical tweezers.

Method used

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  • Super-resolution and microscopic analysis MOT (magnetic-optical tweezer) device
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  • Super-resolution and microscopic analysis MOT (magnetic-optical tweezer) device

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Embodiment Construction

[0018] The following description and drawings illustrate specific embodiments of the invention sufficiently to enable those skilled in the art to practice them. Other embodiments may incorporate structural, logical, electrical, process, and other changes. The examples merely represent possible variations. Individual components and functions are optional unless explicitly required, and the order of operations may vary. Portions and features of some embodiments may be included in or substituted for those of other embodiments.

[0019] Biomolecules: Biomolecules are molecular structures, and each biological cell is composed of these important biomolecules and water. These molecules include deoxyribonucleic acid (DNA), ribonucleic acid (RNA), proteins, sugars and fats. They are also composed of organic compound molecules with lower relative molecular weight, including high-energy compounds such as amino acids, fatty acids, sugars, purines, pyrimidines, mononucleotides, porphyri...

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Abstract

The invention provides a super-resolution and microscopic analysis MOT (magnetic-optical tweezer) device. The device comprises a first OT (optical tweezer), a second OT, a magnetic field, polystyrenemicrobeads and ferromagnetic microbeads, wherein the polystyrene microbeads are captured by the second OT, and the ferromagnetic microbeads are captured by the first OT; and the ferromagnetic microbeads are operated by the magnetic field to form a MT (magnetic tweezer). The magnetic field and an optical field can be controlled in strength and position, motion is non-mechanical motion, and the samemicrobead can be simultaneously captured and operated. The magnetic field generated by the MT is generated by a current coil, and no magnetic influence is produced on other articles during working. Operation of the MT is realized by changing magnitude and direction of input current, no mechanical motion is produced, and the operation accuracy and stability of the MT are greatly improved. The OT is generated by two or more laser, so that the OT is more precise to control.

Description

technical field [0001] The invention belongs to the field of microscopic technology, in particular to a super-resolution microscopic analysis magneto-optical tweezers device. Background technique [0002] Molecular forces and torques play important roles in biology, driving biodynamics and chemical processes. The Magneto-Optical Tweezer (MOT) device built using magnetic and optical technologies can precisely measure and control the force and / or torque between these biomolecules, and can describe biological structures and dynamics at the molecular level. Dynamics, mechanics, and changes in structure, function, and interactions can be fully explored, providing a more complete physiological picture. Both Optical Tweezer (OT) and Magnetic Tweezer (MT) have severe limitations in simultaneously measuring and controlling molecular force and torque. Optical tweezers are ideal tools for studying molecular forces, but they have certain limitations in manipulating torque. Although t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/01G01N21/64
CPCG01N21/01G01N21/6408G01N21/6428G01N21/6456G01N21/6458G01N21/6486G01N2021/0112
Inventor 罗华程雍高斌
Owner 武汉铢寸科技有限公司
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