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Compound for dispelling freckles and eliminating fine lines, dark under-eye circles and baggy eyelids, and preparation method of compound

A compound, dark circle technology, applied in the directions of steroids, cosmetic preparations, skin care preparations, etc., can solve the problems of excessive accumulation of metabolic waste, pigmentation of the eyes, insufficient tissue supply, etc. Effects of blood flow, improvement of dark circles, reduction of vascular permeability

Active Publication Date: 2019-12-20
张传旋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to the slow blood flow of the eye skin blood vessels, stagnation is formed, insufficient tissue supply, excessive accumulation of metabolic waste in the blood vessels, resulting in eye pigmentation and dark circles, and because the eye skin is relatively fragile, after dark circles appear , not easy to fade, seriously affect the appearance

Method used

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  • Compound for dispelling freckles and eliminating fine lines, dark under-eye circles and baggy eyelids, and preparation method of compound
  • Compound for dispelling freckles and eliminating fine lines, dark under-eye circles and baggy eyelids, and preparation method of compound
  • Compound for dispelling freckles and eliminating fine lines, dark under-eye circles and baggy eyelids, and preparation method of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The method of mogrosin alcohol derivative shown in formula (I), it comprises:

[0056] Step a, weigh 5g of sodium periodate in an Erlenmeyer flask, dissolve it with 50ml of water (1ml of acetic acid to aid dissolution), then add 50ml of acetone (keep the solvent system as acetone:water=1:1), and set aside; Dissolve 5 g of mogrosin in a round bottom flask with 50 ml of acetone, then add 50 ml of water, stir at 60°C and slowly add the freshly prepared sodium periodate solution, complete the addition within 30 minutes, and react in the dark for 20 hours, evaporate the acetone under reduced pressure, Dilute with an appropriate amount of water, extract three times with dichloromethane, combine the organic phases, dry over anhydrous magnesium sulfate, evaporate the solvent under reduced pressure, separate and purify by silica gel column chromatography (dichloromethane / ethyl acetate=4:1), and obtain intermediate Body A;

[0057] Step b, weigh intermediate A3g in a 250ml round...

Embodiment 2

[0061] The method of mogrosin alcohol derivative shown in formula (I), it comprises:

[0062] Step a, weigh 5g of sodium periodate in an Erlenmeyer flask, dissolve it with 50ml of water (1ml of acetic acid to aid dissolution), then add 50ml of acetone (keep the solvent system as acetone:water=1:1), and set aside; Dissolve 5 g of mogrosin in a round bottom flask with 50 ml of acetone, then add 50 ml of water, stir at 60°C and slowly add the freshly prepared sodium periodate solution, complete the addition within 30 minutes, and react in the dark for 20 hours, evaporate the acetone under reduced pressure, Dilute with an appropriate amount of water, extract three times with dichloromethane, combine the organic phases, dry over anhydrous magnesium sulfate, evaporate the solvent under reduced pressure, separate and purify by silica gel column chromatography (dichloromethane / ethyl acetate=4:1), and obtain intermediate Body A;

[0063] Step b, weigh intermediate A3g in a 250ml round...

Embodiment 3

[0067] A compound for removing freckles, fine lines, dark circles and bags under the eyes, including Mogrosanol methionine ester derivatives and rose pomace alcohol extract in a weight ratio of 1:1.8. Among them, the preparation steps of the rose residue alcohol extract are: adding rose residue to 50% ethanol solution according to the ratio of material to liquid 1:25 (g / mL) and then placing it in an ultrasonic extractor, ultrasonically assisted extraction for 45 minutes, and filtering to remove the suspended extract. particles, take the filtrate and centrifuge at 13,000 rpm for 15 minutes, collect the supernatant, remove the extractant by rotary evaporation, and vacuum freeze-dry to obtain the rose pomace alcohol extract.

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Abstract

The invention provides a compound for dispelling freckles and eliminating fine lines, dark under-eye circles and baggy eyelids, and a preparation method of the compound, and belongs to the technical field of cosmetics. The compound comprises a siraitia grosvenorii alcohol derivative as shown in a formula (I), and a rose flower residue alcohol extract, wherein a preparation method of the siraitia grosvenorii alcohol derivative comprises the steps of oxidizing an o-hydroxyl structure of siraitia grosvenorii alcohol into aldehyde, then reducing an aldehyde group structure into hydroxyl, then performing condensation on the hydroxyl and a BOC-amino acid carboxyl group, and removing BOC so as to obtain the siraitia grosvenorii alcohol derivative as shown in the formula (I). The preparation method of the compound comprises the step of uniformly mixing the siraitia grosvenorii alcohol derivative as shown in the formula (I) with the rose flower residue extract so as to obtain the compound. Thesiraitia grosvenorii alcohol derivative disclosed by the invention can dispel freckles depositing on skin surface, remove fine lines and wrinkles on the skin surfaces and improve the dark under-eye circles and the baggy eyelids. According to the compound disclosed by the invention, rose flower residue alcohol is used, so that the bioactivity of the siraitia grosvenorii alcohol derivative can be reinforced, and the effects of the compound for dispelling the freckles and removing the fine lines, the dark under-eye circles and the baggy eyelids can be improved.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a compound for removing freckles, fine lines, dark circles and bags under the eyes and a preparation method thereof. Background technique [0002] Skin aging is a complex process of skin physiological structure disorder and functional degeneration with aging. It is affected by internal and external factors at the same time, and generally manifests in two forms: natural aging and photoaging. Natural aging is mainly caused by endogenous factors such as genetics, and it gradually appears with the passage of time. It is mostly manifested in fine and shallow wrinkles, dry, loose and rough skin. Photoaging is caused by external environmental factors such as long-term ultraviolet radiation. The clinical characteristic changes include thick and deep wrinkles, decreased elasticity, and spot-like pigmentation. Collagen is one of the most basic components of the extracellular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/63A61K8/9789A61Q19/00A61Q19/02A61Q19/08C07J9/00
CPCA61K8/63A61K8/9789A61Q19/005A61Q19/08A61Q19/02C07J9/00
Inventor 张传旋
Owner 张传旋
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