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Application of physcion-8-O-beta-D-glucopyranoside in prevention and treatment of depression and corresponding drug

A technology of glucopyranoside and emodin methyl ether, which is applied in the field of medicine, can solve the problem of blank activity research, and achieve the effects of broadening application scenarios, definite curative effect, and good control effect.

Pending Publication Date: 2019-11-19
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on the activity of emodin-8-O-β-D-glucopyranoside is still blank

Method used

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  • Application of physcion-8-O-beta-D-glucopyranoside in prevention and treatment of depression and corresponding drug
  • Application of physcion-8-O-beta-D-glucopyranoside in prevention and treatment of depression and corresponding drug
  • Application of physcion-8-O-beta-D-glucopyranoside in prevention and treatment of depression and corresponding drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: mouse experiment

[0019] 1. Behavioral despair (BD) depression model

[0020] The BD model includes the Forced Swimming Test (FST) and the Tail Suspension Test (TST), the theoretical basis of which is: Under the stress conditions of forced swimming or tail suspension, the animal will appear desperate after struggling, that is, immobility, and antidepressants can shorten the immobility time of animals. The former uses the immobility time of animals in the water, and the latter uses the immobility time of animals after being suspended as an index to evaluate the degree of depression. Because the behavioral changes of such model animals can be almost reversed by most antidepressants currently used in clinical practice, and are sensitive and simple, they are often used in the rapid screening of antidepressants and are currently the most widely used screening methods for antidepressants. animal models. However, there are many factors that affect the BD mode...

Embodiment 2

[0052] Embodiment 2: rat experiment

[0053] 1. Chronic Unpredictable Stimulus (CUMS) Model

[0054] After weighing the body weight of the experimental rats, 60 rats were randomly divided into 6 groups, 10 in each group; respectively: control group, model group, fluoxetine control group (10 mg·kg -1 ), emodin-8-O-β-D-glucopyranoside (PSG) low, medium, high (20mg·kg -1 , 40mg·kg -1 , 80mg·kg -1 ) dose group. The rats in each group were acclimatized to the environment for 1 week before the experiment, and then a 4-week chronic unpredictable mild stimulus depression model was constructed. Rats in the control group ate and drank normally without any stimulation; the rest of the groups used one stress method every day to avoid repetition. Stress methods included day and night reversal for 24 hours, cage tilting at 45° for 24 hours, swimming in ice water at 4°C for 5 minutes, restraint for 3 hours, wet bedding for 24 hours, tail clamping for 1 minute, water deprivation for 24 h...

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Abstract

The invention discloses a use of physcion-8-O-beta-D-glucopyranoside in prevention and treatment of depression. The invention also provides a drug for preventing and treating depression. The drug is prepared by using physcion-8-O-beta-D-glucopyranoside as an active ingredient and adding pharmaceutically acceptable excipients or adjuvant ingredients. The drug has good prevention and treatment effects on endogenous depression, reactive depression, occult depression, secondary depression caused by drugs, menopause or postpartum depression, depression induced by head trauma or stroke, depressive neurosis and the like, and the drug has definite curative effects, no addiction and dependence, and no obvious side effects. A new use of physcion-8-O-beta-D-glucopyranoside is provided, application scenarios of physcion glucoside are broadened, and a new scheme for prevention and treatment of depression is found.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of emodin methyl ether-8-O-β-D-glucopyranoside in preventing and treating depression and the corresponding medicines. Background technique [0002] Depression is a major disease with a high incidence rate. Depression is a common psychiatric disease. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world and the second largest disease burden in China. It is predicted that by 2020, it may become the second largest disease after coronary heart disease. disease, which accounts for 15% of the global disease burden. The lifetime incidence of depression is between 6% and 8%. With the gradual aging of the population, the incidence of depression among people over 60 years old will be as high as 20% to 50%. Depressed patients are high-risk groups of suicide, and there is always the risk of suicide from...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P25/24
CPCA61K31/704A61P25/24
Inventor 吴晓青甘元震蒋合众李加洪
Owner SOUTHWEST JIAOTONG UNIV
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