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Preparation method and application of total physalin extract

A technology of physalis and extract, which is applied in the field of preparation of total physalis extract, can solve the problem of less research on the preparation method of total physalis and no total physalis eczema and psoriasis disease

Active Publication Date: 2019-11-15
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are few studies on the preparation method of the total physalis extract from Jindenglong, and there are no relevant reports on the use of total physalis in the treatment of eczema and psoriasis

Method used

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  • Preparation method and application of total physalin extract
  • Preparation method and application of total physalin extract
  • Preparation method and application of total physalin extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of total physalis extract, the specific steps are as follows:

[0029] (1) extract the brocade lantern with 30 times the amount of 70% ethanol twice, each time for 2 hours, to obtain brocade lantern extract;

[0030] (2) Slowly pass the brocade lantern extract with a concentration of 8.338mg / mL~16.675mg / mL through the pretreated AB-8 macroporous resin chromatographic column at a flow rate of 1BV / h, absorb for 1h, and use 2BV of distilled water at 2BV / h flow rate flushing;

[0031] (3) After the Molish reaction of the eluent is negative, elute with 50% ethanol at a flow rate of 2BV / h, collect the eluate between 0.3 and 0.8BV, concentrate it to dryness under reduced pressure, and obtain the total acid slurry Bitter extract. The total physalis content of the effective parts all reaches more than 70%, and the recovery rate of the total physalis reaches more than 85%.

Embodiment 2

[0032] The preparation of embodiment 2 gel

[0033] The concrete composition of gel is as follows: total physalis bitter element extract 0.4g, carbomer (940) 0.7g, glycerol 10g, propylene glycol 5g, menthol 0.1g, ethylparaben 0.1g, triethanolamine regulates pH to 6-7.

[0034] The specific preparation method of the gel is as follows: Weigh 2 g of carbomer (940) and dissolve it in 100 mL of water, swell overnight, take 35 g of swelling matrix as phase I; mix 10 g of glycerin and 5 g of propylene glycol evenly, and add it to phase I to form Phase II: Dissolve 0.4g of total Physalis extract in 20mL of 30% ethanol solution, and after uniform dissolution, add the drug-alcohol solution into Phase II to obtain Phase III; weigh 0.1g of menthol and 0.1g of nipal Dissolve gold ethyl ester in 10mL of 50% alcohol solution, dissolve evenly and add to phase III to form phase IV; add triethanolamine dropwise to phase IV to adjust the pH to 6-7; finally add distilled water to 100g and stir t...

Embodiment 3

[0035] The preparation of embodiment 3 ointment

[0036] The preparation method of the ointment is as follows: take the clear ointment (total physalis extract) concentrated to a relative density of 1.25-1.28 (70°C), add it to 912g of matrix (matrix preparation: take white vaseline and lanolin at a ratio of 1:5 60°C heating and melting), stir well, let cool to below 40°C, add 2‰ borneol that is ground into fine powder, stir well, add 2‰ ethyl paraben that is ground into fine powder, stir well , made into 1000g to get ointment.

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Abstract

The invention discloses a preparation method and application of a total physalin extract, belongs to the technical field of extraction of effective components of traditional Chinese medicines, and discloses the preparation method of the total physalin extract. The method comprises the processes of extraction and enrichment. The total physalin extract can be used for preparing a medicine for treating eczema and psoriasis.

Description

technical field [0001] The invention relates to the technical field of extraction of effective components of traditional Chinese medicines, and more specifically relates to a preparation method and application of total physalis picrin extract. Background technique [0002] Brocade lantern (Physalis alkekengi L var.franchetii (Mast.) Makino) is the dry persistent calyx or persistent calyx with fruit of the perennial herbaceous plant of the Solanaceae (Solanaceae) genus Physalis, also known as red girl, hanging golden lamp, etc. . Persistent calyx tastes bitter, fruit tastes sweet, slightly sour, cold in nature. Originated in China, it is mainly distributed in Northeast, Northwest, Inner Mongolia and other places, and it is also distributed in countries such as America, South Korea and Japan. Brocade lantern has the effects of clearing away heat, detoxifying, phlegm and phlegm, and diuresis. It is used for sore throat, hoarseness, cough due to phlegm heat, dysuria, and exter...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P17/06A61P17/04A61P17/00
CPCA61K36/81A61K2236/333A61K2236/39A61K2236/55A61P17/00A61P17/04A61P17/06
Inventor 舒尊鹏杨燕妮丁子禾钟仁兴王毅夏天乙王武静
Owner GUANGDONG PHARMA UNIV
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