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Use of small molecule compound aminoxyacetic acid in preparing medicine for treating asthma

A small molecule compound, the technology of aminooxyacetic acid, which is applied in the field of small molecule compound aminooxyacetic acid to prepare asthma drugs, can solve the problem of not being able to fundamentally inhibit the attack of asthma, and achieve the goal of relieving lung inflammation and asthma symptoms Effect

Inactive Publication Date: 2019-11-15
CHILDRENS HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment strategies for allergic asthma rely on glucocorticoids, long-acting β2-receptor agonists, etc., but they are all symptomatic treatments and cannot fundamentally inhibit asthma attacks

Method used

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  • Use of small molecule compound aminoxyacetic acid in preparing medicine for treating asthma
  • Use of small molecule compound aminoxyacetic acid in preparing medicine for treating asthma
  • Use of small molecule compound aminoxyacetic acid in preparing medicine for treating asthma

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Embodiment Construction

[0017] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0018] 1. Materials and methods

[0019] 1. Experimental animals

[0020] 6-8 week old female C57BL / 6 mice were purchased from Shanghai Slack Experimental Animal Co., Ltd. They were kept in the Department of Experimental Animal Science of Fudan University or the animal room of the Children's Hospital Affiliated to Fudan University, and the breeding environment met the SPF environmental facility standards. The experimental protocol was approved by the Ethics Committee of the Children's Hospital of Fudan University.

[0021] 2. Establishment of mouse asthma model and intervention of AOA

[0022] According to the published method of the laboratory (XU T, ZHOU Y, QIU L, et al. Aryl HydrocarbonReceptor Protects Lungs from Cockroach Allergen-Induced Inflammation by Modulating Mesenchymal Stem Cells [J]. J Immunol, 2015), the cockroaches were instilled in t...

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Abstract

The invention discloses use of a small molecule compound aminoxyacetic acid in preparing a medicine for treating asthma. A mouse asthma model is established by using a sputum allergen, the mice are divided into a control group, an asthma group and an asthma intervention group, and the airway resistance, the pathological section, and the number of inflammatory cells in the bronchoalveolar lavage fluid are used to determine the severity of the disease in mice. The intervention of aminooxyacetic acid in the present invention can increase the proportion of Foxp3<+>Treg cells in the hilar lymph nodes, and can improve the severity of asthma, which is manifested by a decrease in pulmonary allergic inflammation, comprising a reduction in infiltration of inflammatory cells around the bronchi and adecrease in the proliferation of goblet cells, as well as eosinophils, lymphocytes and neutrophils in BALFs. In addition, the airway resistance of AOA-treated mice is significantly lower than that ofthe asthma group. The AOA of the present invention can be used as a potential drug for the treatment of asthma.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the use of a small molecular compound aminooxyacetic acid in the preparation of medicines for treating asthma. Background technique [0002] Asthma is a chronic respiratory disease induced by allergens. Symptoms include wheezing, shortness of breath, and dyspnea. Severe cases can be life-threatening. It is characterized by chronic inflammation of the respiratory tract and airway hyperresponsiveness. In recent years, the incidence of asthma has been increasing and has become an important public health problem. The current treatment strategies for allergic asthma rely on glucocorticoids, long-acting β2-receptor agonists, etc., but they are all symptomatic treatments and cannot fundamentally inhibit asthma attacks. [0003] Naive CD4 + T cells can be differentiated into various T helper cells (T helper), including Th1, Th2, Th9, Th17 and T-Regulatory cell (Treg) cells. Each different...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P11/06A61P37/08A61P11/00
CPCA61K31/198A61P11/06A61P37/08A61P11/00
Inventor 周玉峰孙立成
Owner CHILDRENS HOSPITAL OF FUDAN UNIV
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