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Preparation method of lemon calcium malate tablet

A technology of calcium malate and calcium citrate, which is applied in pill delivery, metabolic diseases, drug combination, etc., can solve problems affecting the absorption of nutrients in calcium tablets, backward calcium tablet manufacturing technology, and low quality of finished calcium tablets, achieving Improvement of manufacturing process, improvement of quality, and improvement of absorption effect

Inactive Publication Date: 2019-08-23
河南爱心堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the composition of lemon calcium malate tablets in the prior art is relatively simple, and the nutritional supplement to the human body is relatively small. For the problem of absorption of nutrients in calcium tablets, a preparation method of lemon calcium malate tablets is proposed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of lemon calcium malate tablet proposed by the present invention comprises the following raw materials in parts by weight: 80 parts of calcium citrate, 6 parts of polydextrose, 5 parts of DL-malic acid, 6 parts of sodium carboxymethyl starch, povidone K30 2 parts, magnesium stearate 0.6 parts, carmine 0.4 parts.

[0026] The preparation method of lemon calcium malate tablet comprises the following steps:

[0027] S1, Raw material processing: Calcium citrate, DL-malic acid, polydextrose and sodium carboxymethyl starch are passed through 80-mesh sieve respectively, then put into a clean container, and weighed and recorded;

[0028] S2, pulping: preparing 10% povidone K30 pulp;

[0029] S3, granulation: add calcium citrate, DL-malic acid, polydextrose, and sodium carboxymethyl starch into the high-efficiency wet granulator mixer, mix and stir for 5 minutes, then add povidone K30 slurry in S2, and stir 5 minutes, made soft material;

[0030] S4, dry granulation: p...

Embodiment 2

[0035] A kind of lemon calcium malate tablet that the present invention proposes comprises the raw material of following weight portion: 80 parts of calcium citrate, 6 parts of polydextrose, 6 parts of malic acid, 5 parts of sodium carboxymethyl starch, 2 parts of povidone K30, 0.6 parts of magnesium stearate, 0.4 parts of carmine.

[0036] The preparation method of lemon calcium malate tablet comprises the following steps:

[0037] S1, Raw material processing: Calcium citrate, DL-malic acid, polydextrose, and sodium carboxymethyl starch were respectively passed through 80-mesh sieves, then put into a clean container, and weighed and recorded;

[0038] S2, pulping: prepare 10% povidone K30 pulp;

[0039] S3, granulation: add calcium citrate, DL-malic acid, polydextrose, and sodium carboxymethyl starch into the high-efficiency wet granulator mixer, mix and stir for 5 minutes, then add povidone K30 slurry in S2, and stir 5 minutes, made soft material;

[0040] S4, dry granula...

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Abstract

The invention discloses a preparation method of a lemon calcium malate tablet. The lemon calcium malate tablet is prepared from, by weight, 80 parts of calcium citrate, 6 parts of polydextrose, 5 parts of malic acid, 6 parts of sodium carboxymethyl starch, 2 parts of povidone K30, 0.6 part of magnesium stearate and 0.4 part of carmine. The method comprises the following steps of S1, raw material treatment, wherein the calcium citrate, the DL-malic acid, the polydextrose and the sodium carboxymethyl starch are separately screened by a 80-mesh sieve, then the mixture is placed into a clean vessel for weighing, and the weight is recorded; S2, pulping, wherein 10% povidone K30 pulp is prepared; S3, granulating; S4, drying and granulating; S5, mixing. According to the method, through the arrangement of the calcium citrate, the polydextrose, the malic acid, the sodium carboxymethyl starch, the povidone K30, the magnesium stearate, the carmine and other raw and auxiliary materials, the nutritional supplement effect of medicine on the human body is improved; meanwhile, the quality of finished calcium tablet products is improved through the improvement of a manufacturing process, so that the absorption effect of the nutrient components in the calcium tablet by the human body is improved.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a preparation method of lemon calcium malate tablets. Background technique [0002] Calcium is the most abundant mineral element in the human body. Basically all life processes require the participation of calcium. The human body cannot synthesize calcium by itself and must ingest it from the outside world. Various factors will cause various symptoms when calcium intake is insufficient for a long time, which will affect normal growth and development. Before calcium deficiency is discovered, it may have adverse effects on their growth and development and lay hidden dangers for some chronic metabolic diseases in adulthood. [0003] Calcium citrate malate is a compound of organic acids, which is formed by the reaction of calcium carbonate, citric acid and malic acid in a certain proportion. It has the advantages of high solubility, high absorption utilization rate, safety and no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/194A61K47/36A61P3/02
CPCA61K9/205A61K9/2059A61K31/194A61P3/02
Inventor 李婷李长胜范恩高谢玉水
Owner 河南爱心堂生物科技有限公司
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