Novel animal model device for researching skin wound healing

Abstract

The invention belongs to the technical field of biological experimental devices, and particularly relates to a novel small animal model device for researching skin wound healing. The device is characterized by comprising a top cover and a medicine container, and the top cover is provided with an inner pipe and a cover plate; the diameter of the inner pipe is smaller than that of the cover plate, one end of the inner pipe is arranged on the lower surface of the cover plate and is connected with the cover plate into a whole, and a vent hole is formed in the cover plate; the air hole is formed inthe inner diameter range of the inner pipe; the medicine container is sequentially provided with a connecting pipe, a pipe wall, a perforated wing and a bottom which share a common inner diameter from top to bottom, the diameter of the pipe wall is the same as that of the bottom, the diameter of the connecting pipe is smaller than that of the perforated wing, and the diameter of the connecting pipe is larger than that of the pipe wall or the bottom; a needle inlet hole is formed in the perforated wing and is used for a sewing needle to penetrate; when the device is in use, the inner pipe of the top cover is inserted into the connecting pipe, and the outer wall of the inner pipe is tightly attached to the inner wall of the connecting pipe. The device is simple in structure, and facilitatesvisual observation and research.

Description

technical field [0001] The invention belongs to the technical field of biological experiment devices, in particular to a novel small animal model device for studying skin wound healing. Background technique [0002] The incidence of maxillofacial and systemic skin and soft tissue defects caused by trauma, tumor resection, etc. has increased year by year, causing certain economic, social and public health burdens. In the process of studying the healing mechanism of refractory skin wounds and promoting the development of related medical sciences, it is essential to use experimental animals. Due to structural and physiological differences between humans and animals, preclinical research data may have huge changes due to the selection of animal models, so the selection of preclinical experimental animals and the establishment of models are very important. [0003] The current preclinical model of wound healing is mainly the mouse splint model. This method is simple to operate ...

AI Technical Summary

Problems solved by technology

However, there are also the following problems: 1. The splint fixing material is easy to fall off and move; 2. The influence of contraction force on wound healing cannot be completely ruled out, which reduces the credibility of the experimental results; 3. The wound surface is not protected; 4. Not applicable to the study of gel-like drugs with certain fluidity for topical application

And for the research of loading with a certain fluidity and topical drugs (such as: gel), it needs to be able to remain on the wound surface for a long time, and the current splint fixation model has obvious deficiencies, etc.

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