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Use of tumor-derived IgG in the diagnosis or prognosis of pancreatic cancer

A technology for pancreatic ductal adenocarcinoma, which is applied in the fields of prognosis, clinical diagnosis and medicine, and can solve the problem of lack of molecular prognostic markers.

Active Publication Date: 2021-05-04
PEKING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, accurate and effective molecular prognostic markers for pancreatic cancer are still lacking[6-8]

Method used

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  • Use of tumor-derived IgG in the diagnosis or prognosis of pancreatic cancer
  • Use of tumor-derived IgG in the diagnosis or prognosis of pancreatic cancer
  • Use of tumor-derived IgG in the diagnosis or prognosis of pancreatic cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0062] The following experiments were reviewed by the Ethics Committee of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, and complied with the Declaration of Helsinki. All patients were informed of the purpose of sample collection and storage in detail and signed a written consent form.

[0063] 1. Case and experimental design

[0064] A total of 326 cases of pancreatic ductal adenocarcinoma diagnosed by pathology after radical surgery were included. The pathological diagnosis and staging standards refer to the Seventh Edition of the American Cancer Society Cancer Staging Manual.

[0065] Exclusion criteria included: preoperative radiotherapy and chemotherapy, perioperative death, receiving unknown chemotherapy regimens other than gemcitabine and S1, and lack of follow-up data. Through age and gender matching, 326 cases were stratified and randomly divided into training set and validation set, both including 163 cases. Median follow-up time was 1...

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Abstract

The present application relates to the use of tumor-derived IgG in the diagnosis or prognosis of pancreatic cancer. This application discloses the application of a monoclonal antibody that specifically recognizes the constant region of the heavy chain of human tumor-derived immunoglobulin G (CIgG), which is characterized in that: using immunohistochemistry or immunofluorescence techniques, the pathological score of antibody staining is used to determine whether the pancreatic The degree of pathological differentiation of cancer and the prognosis of patients and the preparation of an immunohistochemical kit for detecting the degree of differentiation of pancreatic cancer and evaluating the prognosis. The technical solution of the present application has important application value for improving the accuracy of pancreatic cancer prognosis assessment in clinical and scientific research work, and provides a basis for individualized diagnosis and treatment of tumors.

Description

technical field [0001] This application relates to the field of medicine. Specifically, it relates to the fields of clinical diagnosis and prognosis. The present application relates to the use of tumor-derived IgG as a prognostic marker for pancreatic tumors. Background technique [0002] Pancreatic cancer is still one of the malignant tumors with the highest mortality rate. The incidence of pancreatic cancer is increasing year by year, but its five-year survival rate is still less than 10%. Relevant literature predicts that pancreatic cancer will become the second malignant tumor in tumor-related mortality within 10 years[1-2]. A number of clinicopathological indicators have been used to evaluate the prognosis of pancreatic cancer patients, including tumor pathological grade, lymph node metastasis, CA19-9 level, etc. [3-5]; some molecular markers, such as Ki-67, mTOR pathway molecules, hedgehog Pathway molecules, etc., have also been applied to the prognosis of pancreati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/57438G01N33/57484G01N33/6854
Inventor 邱晓彦赵玉沛崔铭廖泉由磊黄晶刘乔飞黄歆梅张生华
Owner PEKING UNIV
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