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Application of chitosan oligosaccharide on protection and treatment of drug-induced liver injury

A technology for the treatment of drugs and acute liver injury, applied in the field of biomedicine, can solve problems such as inaccurate curative effect

Inactive Publication Date: 2019-06-18
GUANGDONG PHARMA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are problems such as uncertain efficacy

Method used

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  • Application of chitosan oligosaccharide on protection and treatment of drug-induced liver injury
  • Application of chitosan oligosaccharide on protection and treatment of drug-induced liver injury
  • Application of chitosan oligosaccharide on protection and treatment of drug-induced liver injury

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Embodiment Construction

[0020] The above content of the present invention will be further described in detail below through specific examples. However, it should not be understood that the scope of the above-mentioned subject matter of the present invention is limited only to the following examples. Without departing from the above-mentioned technical idea of ​​the present invention, various replacements or changes made according to ordinary technical knowledge and customary means in this field shall be included in the scope of the present invention.

[0021] In order to illustrate the present invention, we use the BABL / C mouse intraperitoneal injection of acetaminophen-induced acute liver injury model and the in vitro APAP-induced human liver cell L02 injury model to further study the method disclosed in the present invention. illustrate.

[0022] 1. Exploration of the pathological process of acetaminophen-induced liver injury in mice

[0023] 25 male BALB / C mice for 6-8 weeks, adaptively fed for ...

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Abstract

The invention discloses application of chitosan oligosaccharide (COST) with molecular weight less than or equal to 1000 and a method of protecting and treating a drug-induced liver injury. The chitosan oligosaccharide is used for preparing a composition for protecting and treating the drug-induced liver injury, in particular to a composition for protecting and treating the liver injury caused by acetaminophen. The method comprises the following step of administering an effective amount of COST to a subject with the liver injury. Experiments prove that COST regulates abnormal biochemical indexes of a paracetamol-induced liver function, obviously reduces abnormal elevation of ALT and AST in serum of mice induced by the acetaminophen, ameliorates the liver tissue injury induced by the acetaminophen, improves the content of an antidote, glutathione (GSH), in the liver tissue of the liver injury induced by the acetaminophen, improves the oxidation resistance of the liver with an oxidative injury induced by the acetaminophen, and reduces the content of malondialdehyde (MDA) in the liver with the oxidative injury induced by the acetaminophen. The chitosan oligosaccharide is expected to bedeveloped and applied to clinical treatment of the liver injury caused by drugs, and provides better selection for patients.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the medical application of chitosan oligosaccharide with molecular weight ≤ 1000 in protecting and treating drug-induced liver injury. Background technique [0002] Drug-induced liver injury (DILI) refers to the direct toxicity of the drug itself or its metabolites to the liver after the human body is exposed to conventional or high doses of drugs, or the human body is allergic to the drug or its metabolites or Liver injury due to metabolic idiosyncratic reactions. Acetaminophen (APAP) is an analgesic widely used clinically. At therapeutic doses (<4g / d), APAP can cause transient elevations in serum aminotransferases, especially in malnourished, hepatic insufficiency Severe liver damage, even acute liver failure, may occur in people who drink excessively, drink alcohol or take some CYP450-inducing drugs (Acuteliver failure, ALF). It is estimated that about 2,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61P1/16
CPCA61K31/722A61P1/16
Inventor 苏政权
Owner GUANGDONG PHARMA UNIV
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