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Application of balicatib in preparation of anti-filovirus infection drugs

A technology of balicatide and filovirus, which is applied in the field of medicine and can solve the problems such as the anti-filovirus of balicatide which has not been seen

Active Publication Date: 2019-06-11
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After searching the literature, there is no report on the anti-filovirus (including Ebola virus, Marburg virus, Cueva virus) or any anti-viral activity of balicati

Method used

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  • Application of balicatib in preparation of anti-filovirus infection drugs
  • Application of balicatib in preparation of anti-filovirus infection drugs
  • Application of balicatib in preparation of anti-filovirus infection drugs

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Embodiment Construction

[0043] EXAMPLES Anti-Filovirus Activity of Balicatib

[0044] 1. Principle of screening model

[0045] Filovirus entry into host cells is the first step in virus infection, and inhibiting virus entry can effectively block virus infection. The glycoprotein (Glycoprotein, GP) on the surface of the filovirus envelope is a key protein in the process of filovirus entry.

[0046] The present invention applies the filovirus envelope GP gene, including Zaire type Ebola virus Mayinga strain envelope GP gene (EBOV-Mayinga GP, Gene Accession No.L11365), Zaire type Ebola virus Makona strain Envelope GP gene (EBOV-Makona GP, Gene Accession No.KJ660346.2), Sudan type Ebola virus envelope GP gene (EBOV-Sudan GP, ​​Gene Accession No.FJ968794.1), Côte d'Ivoire type Ebola virus Envelope GP gene (EBOV- Forest GP, Gene Accession No.FJ217162.1), Reston type Ebola virus envelope GP gene (EBOV-Reston GP, ​​Gene Accession No.U23152.1), Bendibujo type Ebola virus envelope GP gene (EBOV-Bundibugy...

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Abstract

The present invention discloses an application of balicatib in preparation of anti-filovirus infection drugs and comprises the application of the balicatib in prevention or treatment of the filovirusinfection or the combined application with other antiviral drugs.

Description

technical field [0001] The invention relates to the application of balicatib (CAS: 354813-19-7) in anti-filovirus infection, and belongs to the technical field of medicine. The present invention includes the single or combined use of balicatib in the prevention or treatment of filoviruses. Background technique [0002] Filoviruses belong to the family Filoviridae, including three viruses: Ebola virus (EBOV), Marburg virus (Marburgvirus, MARV), and Cuevavirus (Cuevavirus, LLOV). Both Ebola virus and Marburg virus are controlled viruses and are listed as Class A bioterrorism warfare agents. Live viruses need to be operated in biosafety level 4 (P-4) laboratories [Centers for Disease Control and Prevention / National Institutes of Health. Biosafety in Microbiological and Biomedical Laboratories. 4th ed. Washington, DC: U.S. Department of Health and Human Services, U.S. Government Printing Office; 1999. DHHS Publication CDC 93-8395.]. Human infection with these two viruses can c...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61P31/14
Inventor 郭颖陈盼盼陈勍唐克
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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