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Preparation method of magnesium and magnesium alloy with silane/sodium hyaluronate composite coating on surface

A technology of sodium hyaluronate and composite coating, which is applied in coatings, metal material coating processes, etc., can solve the problems of hyaluronidase and free radical sensitivity, poor stability of sodium hyaluronate, and lack of mechanical strength. Achieve good biocompatibility and corrosion resistance, low processing cost and simple process

Active Publication Date: 2020-12-01
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the shortcomings of sodium hyaluronate, such as poor stability, sensitivity to hyaluronidase and free radicals, short retention time in the body, and lack of mechanical strength in water systems, it is necessary to chemically modify it to improve its mechanical properties. Strength and resistance to degradation

Method used

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  • Preparation method of magnesium and magnesium alloy with silane/sodium hyaluronate composite coating on surface
  • Preparation method of magnesium and magnesium alloy with silane/sodium hyaluronate composite coating on surface
  • Preparation method of magnesium and magnesium alloy with silane/sodium hyaluronate composite coating on surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Get pure magnesium metal material to prepare multifunctional coating according to the inventive method:

[0050] A. Mechanical decontamination and cleaning:

[0051] After sanding to 1200#, clean the pure magnesium, and ultrasonically clean it in absolute ethanol for 20 minutes at room temperature;

[0052] B. Hydrothermal treatment:

[0053] The cleaned above-mentioned pure magnesium metal material is placed in a reaction kettle of 120°C, pH=12, and 50% full of NaOH solution for 4 hours; air-cooled to room temperature;

[0054] C. Cleaning:

[0055] The pure magnesium metal material after hydrothermal treatment is ultrasonically cleaned in absolute ethanol for 10 minutes, and dried;

[0056] D. Silanization treatment:

[0057] The configuration method of placing the pure magnesium metal material cleaned in step C into the silane ethanol solution: 7 parts by volume of silane in 100 parts by volume of silane ethanol solution, 8 parts by volume of deionized water, and...

Embodiment 2

[0065] Except that the pure magnesium in step A is replaced by ZM61-Ca0.5 of Mg-Ca alloy, other steps are the same as in Example 1, and a magnesium alloy material with a silane / sodium hyaluronate composite coating on the surface can be obtained.

Embodiment 3

[0067] Except that 120°C in step B was changed to 100°C, and 4h was changed to 6h, the rest of the steps were the same as in Example 1.

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Abstract

The invention discloses a preparing method for the magnesium and magnesium alloy with the surface provided with a silane / sodium hyaluronate composite coating. According to the method, the magnesium and magnesium alloy are subjected to hydro-thermal treatment in an alkaline solution, and a magnesium hydrate film with active hydroxyl is obtained to serve as a substrate with a protection function anda pretreatment layer improving bonding force with silane; then, silane molecules are assembled to the magnesium and magnesium alloy through molecular bonds; and finally, a dipping method is used forobtaining a covalent bond grafted EDC / NHS crosslinking modified sodium hyaluronate coating on the surface of a silanization sample, and the composite coating is obtained after drying. Through the method, the corrosion speed of the magnesium and magnesium alloy can be effectively controlled, the corrosion rate is reduced, introduction of harmful impurities is avoided, and good biocompatibility anddegradability are achieved; a positive role is played for ophthalmic disease treatment through slowly-released magnesium ions, and the success ratio of operation is guaranteed; and the product cost islow, the patient expense is reduced, the method is expected to become a new ophthalmology intervention therapy method, and a new thought is brought for ophthalmic disease treatment.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, in particular to a preparation method of magnesium and magnesium alloys with a silane / sodium hyaluronate composite coating on the surface. Background technique [0002] As a new biomedical degradable magnesium alloy, magnesium and magnesium alloys have the advantages of light weight, high biocompatibility, and non-toxicity. Compared with traditional medical metals (cobalt-based alloys, stainless steel, titanium-based alloys), the largest The feature is that it can be completely degraded in the human body. On the one hand, it can avoid the pain and economic burden brought by the second operation to the patient; Magnesium ions released slowly during degradation can play a pivotal role in the eye, such as: (1) maintain the physiological function of the retina and the normal structure and function of the cornea, (2) regulate the ion level in the cell, (3) As a calcium ion channel blocker, it ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C26/00
Inventor 乔丽英赖宁王勇李伟
Owner CHONGQING UNIV
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