Key protein recognition method based on heterogeneous biological network fusion

A technology of biological network and identification method, applied in biostatistics, bioinformatics, for analyzing two-dimensional or three-dimensional molecular structure, etc., can solve the problem of poor prediction performance of key proteins, and achieve the effect of improving the accuracy of identification

Active Publication Date: 2019-05-24
CHANGSHA UNIVERSITY
View PDF7 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The technical problem to be solved in the present invention is to provide a key protein identification method based on heterogeneous biological network fusion to solve the technical defect of poor key protein prediction performance existing in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Key protein recognition method based on heterogeneous biological network fusion
  • Key protein recognition method based on heterogeneous biological network fusion
  • Key protein recognition method based on heterogeneous biological network fusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0069] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0070] A key protein identification method based on heterogeneous biological network fusion, the process of the method is as follows figure 1 As shown, the weighted protein-protein interaction network, domain-domain interaction network and protein-domain relationship network are mainly established by combining protein interaction network and protein domain information; Based on the source information and subcellular localization information, the initialization score vectors of proteins and domains are established, and the key proteins are identified based on the random walk model.

[0071] In this embodiment, taking yeast protein as an example, the method is run on the yeast protein interaction network to verify the effectiveness of the present invention. The specific method includes the following detailed steps.

[0072] S1: Acquir...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a key protein recognition method based on heterogeneous biological network fusion. The key protein recognition method includes the steps: obtaining a yeast protein interactionnetwork topology, protein domain information, protein homology information, and protein subcellular localization information; respectively establishing a protein-protein interaction network P_G, a structural domain-structural domain interaction network D_G and a protein-structural domain network PD_G; fusing the three networks PD_G three networks, and establishing a heterogeneous network HG; establishing an initialized score vector h0 of the protein and structural domain; iteratively calculating the score vector h(i)t( / i) of the protein and structural domain based on a random walk model untila steady state is achieved; and sorting according to the score of the protein in the steady state, and identifying the key protein. The key protein recognition method based on heterogeneous biologicalnetwork fusion improves the fusion mode of multi-source biological data in the research of key protein recognition methods, and greatly improves the recognition accuracy of key proteins.

Description

technical field [0001] The invention relates to the field of systems biology, in particular to a method for identifying key proteins based on fusion of heterogeneous biological networks. Background technique [0002] After being deleted, the protein that causes the loss of function of the protein complex and causes the organism to fail to survive or develop is called a key protein. Identifying key proteins helps to understand the minimum requirements for cell survival and development, and plays a vital role in synthetic biology. role. The study of key proteins provides valuable information for medicine and other related disciplines, especially in disease diagnosis and treatment, and drug design has important application prospects. In biology, key proteins are mainly identified through biomedical experiments. These methods are costly, inefficient, and applicable to limited species. Therefore, proposing efficient computational methods for identifying key proteins has become o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G16B15/20G16B40/20
Inventor 赵碧海胡赛王雷李学勇张志宏
Owner CHANGSHA UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap