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A flexible mesoporous organosilicon nanorod and its preparation method and application

A mesoporous organosilicon and nanorod technology, applied in the field of mesoporous silica materials, can solve the problems of unstable properties of non-spherical nanoparticles, unfavorable application of flexible nanoparticles, limited loading of nanoparticles, etc., and achieve good dispersion of polar solvents. Performance and biocompatibility, uniform size, low equipment requirements

Active Publication Date: 2022-02-15
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Compared with spherical nanoparticles, non-spherical nanoparticles are more unstable in thermodynamics, so most of the flexible nanoparticles reported at this stage are spherical or quasi-spherical, and a single shape is not conducive to the application of flexible nanoparticles in bio- In addition, most of the flexible nanoparticles reported in the past do not have a mesoporous structure, which limits the loading of nanoparticles on therapeutic molecules, which is not conducive to the further development of flexible nanoparticles in the field of biomedicine. application
[0003] So far, the preparation and development of non-spherical flexible mesoporous nanoparticles has not been reported, and the preparation of such nanoparticles is still a challenging task.

Method used

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  • A flexible mesoporous organosilicon nanorod and its preparation method and application
  • A flexible mesoporous organosilicon nanorod and its preparation method and application
  • A flexible mesoporous organosilicon nanorod and its preparation method and application

Examples

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Embodiment 1

[0033] Example 1, Preparation of Flexible Mesoporous Silicone Nanorods

[0034] Step S1, the preparation of gold nanorods adopts the seed crystal induced growth method, and the specific preparation scheme is as follows:

[0035] (1) Synthesis of nano-gold seed solution: All synthesis experiments were completed in a water bath, and the temperature of the water bath was controlled at 30 °C; first, the prepared 0.01 M sodium borohydride (0.0189 g dissolved in a 50 mL volumetric flask) was placed on ice Put the reaction bottle in a water bath at 30-32°C, and add magnetite, chloroauric acid (0.25 mL, 0.01 M), cetyltrimethylammonium bromide (10 mL, 0.1 M ), stirring, and finally adding the reducing agent sodium borohydride (0.6 mL, 0.1 M); stirring for three minutes, and standing for 0.5 h, the reaction solution was brown at this time;

[0036] (2) Synthesis of nano-gold rods—growth of nano-gold species: all synthesis experiments were completed in a water bath, and the temperature ...

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Abstract

The invention discloses a flexible mesoporous organic silicon nanorod and its preparation method and application. The flexible mesoporous organic silicon nanorod has a rod-shaped appearance, a shrunken surface, a large internal cavity and a mesoporous channel , using gold nanorods as the core during preparation, and obtaining a flexible mesoporous organo-silica shell by etching with an alkaline solution, and the skeleton contains both organo-silica and inorganic silica. The preparation process of the flexible mesoporous silicone nanorod is simple, and the finished product has lower Young's modulus and higher cell phagocytosis efficiency, and has great application potential in the fields of drug delivery, nanomedicine imaging and the like.

Description

technical field [0001] The invention belongs to the field of mesoporous silicon oxide materials, in particular to a flexible mesoporous organic silicon nanorod and its preparation method and application. Background technique [0002] In recent years, flexible nanoparticles have gained increasing attention in the biomedical field due to their unique biological properties, including long in vivo circulation time and high cellular uptake efficiency. Compared with spherical nanoparticles, non-spherical nanoparticles are more unstable in thermodynamics, so most of the flexible nanoparticles reported at this stage are spherical or quasi-spherical, and a single shape is not conducive to the application of flexible nanoparticles in bio- In addition, most of the flexible nanoparticles reported in the past do not have a mesoporous structure, which limits the loading of nanoparticles on therapeutic molecules, which is not conducive to the further development of flexible nanoparticles i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K49/00
Inventor 滕兆刚陈昆苏晓丹汪联辉冯志浩
Owner NANJING UNIV OF POSTS & TELECOMM
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