Antibacterial agent containing serratia-marcescens metabolite prodigiosin and preparing method

Abstract

The invention discloses an antibacterial agent containing serratia-marcescens metabolite prodigiosin and a preparing method. A methanol solution of the prodigiosin is added into a glycolic acid watersolution through a polytetrafluoroethylene hollow fiber membrane under the pressure effect, and the prodigiosin is evenly dispersed in an ultrafine-particle manner to form suspension; then the suspension and pregelatinized starch dispersed in a waterborne system are subjected to mixing ball milling, and through the adhesive effect of the pregelatinized starch, it is further promoted that the prodigiosin stably exists in the water environment; finally, polyvinyl-alcohol hollow microspheres are introduced, high-pressure homogenization treatment is conducted, then freezing, heating and drying areconducted, rich porous structures are formed, and microorganisms including bacteria are attracted and gathered, and the prodigiosin can fully play the bactericidal effect. According to the antibacterial agent containing serratia-marcescens metabolite prodigiosin and the preparing method, a bactericide obtained with the method can play the excellent bactericidal effect in an aquaculture system.

Description

technical field [0001] The invention relates to an antibacterial agent, in particular to an antibacterial agent containing prodigiosin, a metabolite of Serratia marcescens, and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] In recent years, the problem of pollution in aquaculture areas in my country has become increasingly serious, and the problem of edible safety of aquatic products has become increasingly prominent. With the increase of urban sewage discharge, the aquaculture water body is increasingly polluted by microorganisms from domestic sewage. According to investigations, the rate of E. coli in fish, shrimp and crabs cultured in some aquaculture areas is as high as 90%. Such water Long-term intake of the product by the human body will inevitably affect human health. [0003] Prodigiosin is a red metabolite of Serratia marcescens, a general term for a class of natural red pigments with polypyrrole rings, an...

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Problems solved by technology

[0004] However, prodigiosin is insoluble in water. When it is directly put into water, it will basically gather into piles and cannot be fully dispersed in the system, which will affect the antibacterial effect. Therefore, how to exert antibacterial effect in the aquaculture system has become a constraint for other A major problem in the field of aquaculture

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