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A drug compound for treating cholangiocarcinoma and its application

A drug compound and technology for cholangiocarcinoma, applied in the field of drug compound for the treatment of cholangiocarcinoma, can solve the problems of lack of treatment methods and poor prognosis, and achieve the effect of treating cholangiocarcinoma and delaying the progress of cholangiocarcinoma

Active Publication Date: 2021-07-20
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is more aggressive than hepatocellular carcinoma, only 30%-40% of patients can be effectively treated by surgical resection at the time of diagnosis, and most of the patients are already at an advanced stage when they are diagnosed, lacking effective treatment methods, and the prognosis is extremely poor Difference

Method used

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  • A drug compound for treating cholangiocarcinoma and its application
  • A drug compound for treating cholangiocarcinoma and its application
  • A drug compound for treating cholangiocarcinoma and its application

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Embodiment Construction

[0035] The present invention is described in more detail with reference to the following examples, however, the following examples are provided only to illustrate the present invention and should not be construed as limiting the scope and application of the present invention.

[0036] Cytological experiments on cholangiocarcinoma confirmed that levamisole and acitretin synergistically promoted the apoptosis of cholangiocarcinoma cells CCLP-1 and QBC-939 under aerobic and anaerobic culture conditions, and significantly inhibited the growth of cholangiocarcinoma cells.

[0037] Clinically, we applied levamisole hydrochloride and acitretin capsules to patients with cholangiocarcinoma, which significantly inhibited the progression of tumors in patients with cholangiocarcinoma, inhibited the increase of tumor markers, and achieved very positive and significant results.

[0038] Pharmacological analysis

[0039] The present invention provides a drug compound for treating cholangioca...

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Abstract

The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical compound for treating cholangiocarcinoma and its application. A drug complex for treating cholangiocarcinoma, the basic active ingredient is composed of the following two drugs: a, levamisole or a pharmaceutically acceptable salt thereof; b, acitretin. The compound preparation is suitable for various solid tumors mainly manifested by hypoxia, such as cholangiocarcinoma. The results of cytological experiments on cholangiocarcinoma and the practice of clinical cases show that in terms of indications, the drug ingredients can produce obvious synergistic effects, significant curative effect, convenient and safe use, greatly reducing treatment costs, and are suitable for clinical use widely used.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical compound for treating cholangiocarcinoma and its application. Background technique [0002] Cholangiocarcinoma is the second most common malignant tumor of the hepatobiliary system after hepatocellular carcinoma. According to statistics, the overall mortality rate of hepatobiliary malignancies ranks fifth among all malignancies. my country is an area with a high incidence of cholangiocarcinoma, and the incidence has been increasing in recent years. It is more aggressive than hepatocellular carcinoma, only 30%-40% of patients can be effectively treated by surgical resection at the time of diagnosis, and most of the patients are already at an advanced stage when they are diagnosed, lacking effective treatment methods, and the prognosis is extremely poor Difference. Therefore, it is urgent to find new and effective treatment options. [0003] Levamisol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/429A61K31/203A61P35/00
Inventor 余祖江
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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