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Novel sustainable sustained-release method for biofilm inhibiting molecule

A biofilm and molecular technology, applied in fertilizer mixtures, fertilization devices, applications, etc., can solve the problems of short anti-biofilm pollution cycle and low utilization rate of D-amino acid, to achieve long-term control of biofilm pollution and improve utilization rate , the effect of prolonging the release time

Active Publication Date: 2019-05-03
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to provide a sustainable slow-release method for novel biofilm inhibitory molecules to solve the problems of low utilization rate of D-amino acid and short cycle of anti-biofilm pollution, so as to realize long-term control of biofilm pollution

Method used

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  • Novel sustainable sustained-release method for biofilm inhibiting molecule
  • Novel sustainable sustained-release method for biofilm inhibiting molecule
  • Novel sustainable sustained-release method for biofilm inhibiting molecule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Acid-modified halloysite (HNTs)

[0029] Weigh the natural halloysite, adopt the concentration of 3M sulfuric acid (H 2 SO 4 ), treated at 50°C for 5h, and then washed with distilled water until neutral. Centrifugal filtration and drying to prepare acid-modified halloysite (H 2 SO 4 / HNTs).

[0030] (2)H 2 SO 4 / HNTs loaded with D-tyrosine (DAA)

[0031] Weigh 50mg of D-tyrosine powder and dissolve in 100mL acetic acid solution, then add 0.5g H 2 SO 4 / HNTs, magnetically stirred at room temperature for 24h. After the loading is completed, it is centrifugally filtered at 4500 rpm, and dried in a vacuum drying oven for use. The loading of D-amino acids was calculated by ninhydrin colorimetry at 570 nm.

[0032] (3) H of load DAA 2 SO 4 / HNTs surface assembled pH-responsive weak polyelectrolyte

[0033] Using layer-by-layer assembly technology in the H loaded with DAA 2 SO 4 / HNTs surface assembled polyallylamine hydrochloride (PAH), polyacrylic acid (P...

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Abstract

The invention relates to a novel sustainable sustained-release method for a biofilm inhibiting molecule D-amino acid. The method comprises the following steps: sulfuric acid-modified halloysite nanotubes are adopted to load a D-amino acid, then cationic and anionic weak polyelectrolytes having pH response characteristics are assembled on the surface of the modified halloysite layer by layer, and therefore the halloysite composite carrier material with pH response characteristics is prepared. According to the method provided by the invention, the composite carrier material prepared by the method effectively improves a utilization ratio of the D-amino acid by sustained release, at the same time, the composite carrier has the reloading ability to the D-amino acid by adjust and control of thepH of the solution, so that the sustainable sustained-release utilization of the biofilm inhibiting molecule D-amino acid is realized, and a novel strategy for long-term control of biofilm contamination is provided.

Description

technical field [0001] The invention belongs to the field of pollution control, and in particular relates to a long-term control method for biofilm pollution. That is, the sustainable utilization of biofilm inhibitory molecule D-amino acid can be realized through slow release and reloading, so as to control biofilm pollution for a long time. Background technique [0002] Biofilm pollution is the formation of bacterial microorganisms that adhere to solid surfaces and secrete extracellular matrix during the growth and reproduction process to adapt to the environment. Due to the widespread distribution of microorganisms in nature, biofilm pollution exists in many fields such as medicine, food, and the environment, causing wound infection, food spoilage, and environmental pollution. It is an important problem facing the development of human social and economic life. At present, various control methods such as high-temperature sterilization, use of fungicides, and development of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C05G3/00C05G3/08C05G3/90
Inventor 郭晓燕范守港王冲
Owner NANKAI UNIV
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